Rabbit SOCS5 Polyclonal Antibody | anti-SOCS5 antibody

SOCS5 Polyclonal Antibody

Cat. Num. AAA2520884

• Gene Names: SOCS5; CIS6; CISH6; Cish5; SOCS-5
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: SOCS5; Polyclonal Antibody; SOCS5 Polyclonal Antibody; CIS6; CISH6; Cish5; SOCS-5; anti-SOCS5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 536

• Applicable Applications for anti-SOCS5 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant protein of human SOCS5
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using SOCS5 Polyclonal Antibody at dilution 1:35)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using SOCS5 Polyclonal Antibody at dilution 1:35)

Related Product Information for anti-SOCS5 antibody

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.

NCBI and Uniprot Product Information

• NCBI GI #: 21618354
• NCBI GeneID: 9655
• NCBI Accession #: NP_659198.1
• NCBI GenBank Nucleotide #: NM_144949.2
• Molecular Weight: 61,246 Da
• NCBI Official Full Name: suppressor of cytokine signaling 5
• NCBI Official Synonym Full Names: suppressor of cytokine signaling 5
• NCBI Official Symbol: SOCS5
• NCBI Official Synonym Symbols: CIS6; CISH6; Cish5; SOCS-5
• NCBI Protein Information: suppressor of cytokine signaling 5; CIS-6; cytokine-inducible SH2 protein 6; cytokine-inducible SH2-containing protein 5
• UniProt Protein Name: Suppressor of cytokine signaling 5
• Protein Family: Suppressor of cytokine signaling
• UniProt Gene Name: SOCS5
• UniProt Synonym Gene Names: CIS6; CISH5; CISH6; KIAA0671; SOCS-5; CIS-6
• UniProt Entry Name: SOCS5_HUMAN

NCBI Description

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

SOCS5: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cytoplasm

Molecular Function: protein binding; protein kinase inhibitor activity; receptor tyrosine kinase binding; epidermal growth factor receptor binding

Biological Process: negative regulation of epidermal growth factor receptor activity; epidermal growth factor receptor signaling pathway; negative regulation of T-helper 2 cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of growth; cytokine and chemokine mediated signaling pathway; protein ubiquitination; positive regulation of T-helper 1 cell differentiation; cell growth; JAK-STAT cascade; negative regulation of JAK-STAT cascade; negative regulation of signal transduction