Rabbit anti-Mouse Smarcd1 Polyclonal Antibody | anti-Smarcd1 antibody

Smarcd1, ID (Smarcd1, Baf60a, D15Kz1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1, 60kD BRG-1/Brm-associated factor subunit A, BRG1-associated factor 60A, Protein D15KZ1, SWI/SNF complex 60kD subunit) (PE)

Cat. Num. AAA6348879

• Gene Names: Smarcd1; Baf60a; D15Kz1; AA407987
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Smarcd1; Polyclonal Antibody; ID (Smarcd1; Baf60a; D15Kz1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; 60kD BRG-1/Brm-associated factor subunit A; BRG1-associated factor 60A; Protein D15KZ1; SWI/SNF complex 60kD subunit) (PE); SWI/SNF complex 60kD subunit; anti-Smarcd1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-Smarcd1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Mouse Smarcd1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-335 amino acids from the Central region of mouse Smarcd1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Mouse Smarcd1 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Mouse Smarcd1 antibody detected the Mouse Smarcd1 protein (arrow).)

Related Product Information for anti-Smarcd1 antibody

Smarcd1 is involved in chromatin remodeling. Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancer Vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Product Categories/Family for anti-Smarcd1 antibody

Antibodies; Actin Related Proteins

References

Guo, G., et al. Dev. Cell 18(4):675-685(2010). Ho, L., et al. Proc. Natl. Acad. Sci. U.S.A. 106(13):5181-5186(2009). Li, S., et al. Cell Metab. 8(2):105-117(2008). Oh, J., et al. J. Biol. Chem. 283(18):11924-11934(2008). Valerius, M.T., et al. Gene Expr. Patterns 8(5):297-306(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 125347396
• NCBI GeneID: 83797
• NCBI Accession #: NP_114030.2
• NCBI GenBank Nucleotide #: NM_031842.2
• UniProt Accession #: Q61466; P70384; Q8R0I7
• Molecular Weight: 58,245 Da
• NCBI Official Full Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
• NCBI Official Synonym Full Names: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
• NCBI Official Symbol: Smarcd1
• NCBI Official Synonym Symbols: Baf60a; D15Kz1; AA407987
• NCBI Protein Information: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; BRG1-associated factor 60A; SWI/SNF complex 60 kDa subunit; 60 kDa BRG-1/Brm-associated factor subunit A
• UniProt Protein Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
• Protein Family: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily
• UniProt Gene Name: Smarcd1
• UniProt Synonym Gene Names: Baf60a; D15Kz1; BAF60A
• UniProt Entry Name: SMRD1_MOUSE