Rabbit SLC5A1 / SGLT1 Polyclonal Antibody | anti-SLC5A1 antibody

Rabbit Polyclonal to Human SLC5A1 / SGLT1

Cat. Num. AAA244290

• Gene Names: SLC5A1; NAGT; SGLT1; D22S675
• Reactivity: Human, Orangutan; Predicted Reactivity: Chimpanzee, Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: SLC5A1 / SGLT1; Polyclonal Antibody; Rabbit Polyclonal to Human SLC5A1 / SGLT1; Anti-SLC5A1 / SGLT1 Antibody (Internal) IHC-plus; SLC5A1; D22S675; HSGLT1; Na(+)/glucose cotransporter 1; Na+/glucose cotransporter 1; SGLT1; NAGT; Sodium-glucose transporter 1; Sodium/glucose cotransporter 1; Human SLC5A1; anti-SLC5A1 antibody

• Host: Rabbit
• Reactivity: Human, Orangutan; Predicted Reactivity: Chimpanzee, Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human SLC5A1 / SGLT1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 664

• Applicable Applications for anti-SLC5A1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 - 10 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from internal region of human SLC5A1 / SGLT1. Percent identity with other species by BLAST analysis: Human, Orangutan (100%); Chimpanzee, Gibbon (94%); Monkey (82%).
• Immunogen Type: Synthetic peptide
• Immunogen: SLC5A1 / SGLT1 antibody was raised against synthetic 17 amino acid peptide from internal region of human SLC5A1 / SGLT1. Percent identity with other species by BLAST analysis: Human, Orangutan (100%); Chimpanzee, Gibbon (94%); Monkey (82%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-SLC5A1 / SGLT1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-SLC5A1 / SGLT1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-SLC5A1 antibody

Solute Carrier Family 5 Member 1 (Slc5a1/SGLT1) is a member of the sodium dependent glucose transporters also known as co transporters or symporters. It is an integral membrane protein involved in the active transport of glucose and galactose across the membrane of cells lining the gi tract and kidney. Transport is driven by the sodium/potassium ATPase.

Product Categories/Family for anti-SLC5A1 antibody

Family: Transporter; Subfamily: Solute:sodium symporter

NCBI and Uniprot Product Information

• NCBI GI #: 4507031
• NCBI GeneID: 6523
• NCBI Accession #: NP_000334.1
• NCBI GenBank Nucleotide #: NM_000343.3
• UniProt Accession #: P13866; B2R7E2; B7Z4Q9; B7ZA69
• Molecular Weight: 60,097 Da
• NCBI Official Full Name: sodium/glucose cotransporter 1 isoform 1
• NCBI Official Synonym Full Names: solute carrier family 5 (sodium/glucose cotransporter), member 1
• NCBI Official Symbol: SLC5A1
• NCBI Official Synonym Symbols: NAGT; SGLT1; D22S675
• NCBI Protein Information: sodium/glucose cotransporter 1; Na+/glucose cotransporter 1; high affinity sodium-glucose cotransporter
• UniProt Protein Name: Sodium/glucose cotransporter 1
• Protein Family: Sodium/glucose cotransporter
• UniProt Gene Name: SLC5A1
• UniProt Synonym Gene Names: NAGT; SGLT1; Na(+)/glucose cotransporter 1
• UniProt Entry Name: SC5A1_HUMAN

NCBI Description

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Description

SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: integral to plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; intercellular junction

Molecular Function: protein binding; glucose:sodium symporter activity

Biological Process: hexose transport; sodium ion transport; carbohydrate metabolic process; pathogenesis; glucose transport; transmembrane transport; metanephros development; intestinal absorption

Disease: Glucose/galactose Malabsorption