Rabbit anti-Human SLC5A1 Polyclonal Antibody | anti-SLC5A1 antibody

Anti-SLC5A1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8109440

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: SLC5A1; Polyclonal Antibody; Anti-SLC5A1 Antibody; Rabbit Polyclonal; SLC5A1 Antibody; Rabbit PAb; Antigen Affinity Purified; solute carrier family 5 (sodium/glucose cotransporter); member 1; Anti-D22S675 Antibody; Anti-NAGT Antibody; Anti-SGLT1 Antibody; anti-SLC5A1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human SLC5A1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-SLC5A1 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:5000
• Immunogen: E Coli-derived Human SLC5A1 fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human SLC5A1 fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human SLC5A1 in human duodenum with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining of human SLC5A1 in human small intestine with rabbit polyclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-SLC5A1 antibody

Sodium-glucose cotransporters SGLT1 (encoded by SGLT1, also known as SLC5A1) and SGLT2 (encoded by SGLT2, also known as SLC5A2) are important mediators of epithelial glucose transport. Mutations in the SLC5A1 gene cause glucose/galactose malabsorption, whereas mutations in SLC5A2 are associated with glucosuria. Congenital glucose-galactose malabsorption (cGGM) is a rare autosomal recessive disorder, caused by mutations in the Na(+)/glucose cotransporter gene SLC5A1, which may result in severe life-threatening osmotic diarrhea due to the accumulation of unabsorbed sugars in the intestinal lumen. If treated early with the elimination of glucose and galactose from the diet, patients usually recover and develop normally. More than 300 subjects of diverse origin have been reported worldwide, most of whom are a result of a consanguineous union.

References

Xin B, et al. (2011) Multiple sequence variations in slc5a1 gene are associated with glucose-galactose malabsorption in a large cohort of old order amish. Clin Genet 79 (1): 86-91.Vallaeys L, et al. (2013) Congenital glucose-galactose malabsorption: A novel deletion within the slc5a1 gene. Eur J Pediatr 172 (3): 409-411.Pode-Shakked B, et al. (2014) Bitterness of glucose/galactose: Novel mutations in the slc5a1 gene. J Pediatr Gastroenterol Nutr 58 (1): 57-60.Al-Suyufi Y, et al. (2018) Slc5a1 mutations in saudi arabian patients with congenital glucose-galactose malabsorption. J Pediatr Gastroenterol Nutr 66 (2): 250-252.