Western Blot (WB)
(SLC4A7 Antibody (C-term) western blot analysis in K562 cell line lysates (15ug/lane).This demonstrates the SLC4A7 antibody detected the SLC4A7 protein (arrow).)
Rabbit anti-Human SLC4A7 Polyclonal Antibody | anti-SLC4A7 antibody
SLC4A7 Antibody (C-term)
Western Blot (WB)
(SLC4A7 Antibody (C-term) western blot analysis in K562 cell line lysates (15ug/lane).This demonstrates the SLC4A7 antibody detected the SLC4A7 protein (arrow).)
Western Blot (WB)
(SLC4A7 Antibody (C-term) western blot analysis in K562 cell line lysates (15ug/lane).This demonstrates the SLC4A7 antibody detected the SLC4A7 protein (arrow).)
Immunohistochemistry (IHC)
(SLC4A7 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SLC4A7 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(SLC4A7 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SLC4A7 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Ahmed, S., et al. Nat. Genet. 41(5):585-590(2009)
Ishiguro, H., et al. Addiction 102(8):1320-1325(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
NCBI and Uniprot Product Information
NCBI Description
This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Uniprot Description
SLC4A7: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p22
Cellular Component: stereocilium; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: inorganic anion exchanger activity; sodium:bicarbonate symporter activity
Biological Process: cochlear nucleus development; bicarbonate transport; regulation of intracellular pH; auditory receptor cell development; retinal cell programmed cell death; ion transport; transmembrane transport
Research Articles on SLC4A7
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Product Notes
The SLC4A7 slc4a7 (Catalog #AAA9212361) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1186-1214. The SLC4A7 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC4A7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the SLC4A7 slc4a7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC4A7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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