Rabbit anti-Human SLC30A10 Polyclonal Antibody | anti-SLC30A10 antibody

SLC30A10, CT (SLC30A10, ZNT10, ZNT8, Zinc transporter 10, Solute carrier family 30 member 10) (MaxLight 405)

Cat. Num. AAA6348357

• Gene Names: SLC30A10; ZNT8; ZRC1; HMDPC; ZNT10; ZnT-10; HMNDYT1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SLC30A10; Polyclonal Antibody; CT (SLC30A10; ZNT10; ZNT8; Zinc transporter 10; Solute carrier family 30 member 10) (MaxLight 405); Solute carrier family 30 member 10; anti-SLC30A10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-SLC30A10 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SLC30A10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-359 amino acids from the C-terminal region of human SLC30A10.
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-SLC30A10 antibody

Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra-and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A10, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).

Product Categories/Family for anti-SLC30A10 antibody

Antibodies; Transport Proteins

References

Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008). Seve, M., et al. BMC Genomics 5 (1), 32 (2004).

NCBI and Uniprot Product Information

• NCBI GI #: 52351208
• NCBI GeneID: 55532
• NCBI Accession #: NP_061183.2
• NCBI GenBank Nucleotide #: NM_018713.2
• UniProt Accession #: Q6XR72; Q49AL9; Q9NPW0
• Molecular Weight: 24,009 Da
• NCBI Official Full Name: zinc transporter 10
• NCBI Official Synonym Full Names: solute carrier family 30 member 10
• NCBI Official Symbol: SLC30A10
• NCBI Official Synonym Symbols: ZNT8; ZRC1; HMDPC; ZNT10; ZnT-10; HMNDYT1
• NCBI Protein Information: zinc transporter 10
• UniProt Protein Name: Zinc transporter 10
• Protein Family: Zinc transporter
• UniProt Gene Name: SLC30A10
• UniProt Synonym Gene Names: ZNT10; ZNT8; ZnT-10
• UniProt Entry Name: ZNT10_HUMAN

NCBI Description

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

Uniprot Description

SLC30A10: May be involved in zinc transport out of the cell, being a zinc-efflux transporter. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: integral to membrane; plasma membrane

Molecular Function: cation transmembrane transporter activity

Biological Process: manganese ion transport; zinc ion transport

Disease: Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis