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Western Blot (WB) (SLC30A10 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SLC30A10 antibody detected the SLC30A10 protein (arrow).)

Rabbit anti-Human SLC30A10 Polyclonal Antibody | anti-SLC30A10 antibody

SLC30A10 Antibody (C-term)

Gene Names
SLC30A10; ZNT8; ZRC1; HMDPC; ZNT10; ZnT-10
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SLC30A10; Polyclonal Antibody; SLC30A10 Antibody (C-term); Zinc transporter 10; ZnT-10; Solute carrier family 30 member 10; ZNT10; ZNT8; anti-SLC30A10 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SLC30A10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-359 amino acids from the C-terminal region of human SLC30A10.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
331-359
Sequence Length
485
Applicable Applications for anti-SLC30A10 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Function
Plays a pivotal role in manganese transp ort. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways.
Cellular Location
Cell membrane; Multi-pass membrane protein
Tissue Location
Specifically expressed in fetal liver and fetal brain.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(SLC30A10 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SLC30A10 antibody detected the SLC30A10 protein (arrow).)

Western Blot (WB) (SLC30A10 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SLC30A10 antibody detected the SLC30A10 protein (arrow).)

Western Blot

(Anti-SLC30A10 Antibody (C-term) at 1:2000 dilution + human liver lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)

Western Blot (Anti-SLC30A10 Antibody (C-term) at 1:2000 dilution + human liver lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)

Western Blot

(All lanes : Anti-SLC30A10 Antibody (C-term) at 1:2000 dilution Lane 1: human fetal brain lysate Lane 2: human fetal liver lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)

Western Blot (All lanes : Anti-SLC30A10 Antibody (C-term) at 1:2000 dilution Lane 1: human fetal brain lysate Lane 2: human fetal liver lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)
Related Product Information for anti-SLC30A10 antibody
Zinc functions as a cofactor for numerous enzymes, nuclear
factors, and hormones and as an intra- and intercellular signal
ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the
cation diffusion facilitator family, such as SLC30A10, permit
cellular efflux of zinc (Seve et al., 2004 [PubMed
15154973]).
Product Categories/Family for anti-SLC30A10 antibody
References
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
Seve, M., et al. BMC Genomics 5 (1), 32 (2004) :

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
52684
NCBI Official Full Name
zinc transporter 10
NCBI Official Synonym Full Names
solute carrier family 30, member 10
NCBI Official Symbol
SLC30A10
NCBI Official Synonym Symbols
ZNT8; ZRC1; HMDPC; ZNT10; ZnT-10
NCBI Protein Information
zinc transporter 10
UniProt Protein Name
Zinc transporter 10
Protein Family
UniProt Gene Name
SLC30A10
UniProt Synonym Gene Names
ZNT10; ZNT8; ZnT-10
UniProt Entry Name
ZNT10_HUMAN

NCBI Description

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

Uniprot Description

SLC30A10: May be involved in zinc transport out of the cell, being a zinc-efflux transporter. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: integral to membrane; plasma membrane

Molecular Function: cation transmembrane transporter activity

Biological Process: manganese ion transport; zinc ion transport

Disease: Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis

Research Articles on SLC30A10

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Product Notes

The SLC30A10 slc30a10 (Catalog #AAA9201799) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 331-359. The SLC30A10 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC30A10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SLC30A10 slc30a10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC30A10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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