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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human liver cancer tissue using SLC27A1 Polyclonal Antibody at dilution 1:40)

Rabbit SLC27A1 Polyclonal Antibody | anti-SLC27A1 antibody

SLC27A1 Polyclonal Antibody

Gene Names
SLC27A1; FATP; FATP1; ACSVL5; FATP-1
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
SLC27A1; Polyclonal Antibody; SLC27A1 Polyclonal Antibody; FATP; FATP1; ACSVL5; anti-SLC27A1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
1.1mg/mL (varies by lot)
Sequence Length
240
Applicable Applications for anti-SLC27A1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:200
Immunogen
Synthetic peptide of human SLC27A1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using SLC27A1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human liver cancer tissue using SLC27A1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human lung cancer tissue using SLC27A1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human lung cancer tissue using SLC27A1 Polyclonal Antibody at dilution 1:40)
Related Product Information for anti-SLC27A1 antibody
The protein involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
51,780 Da
NCBI Official Full Name
SLC27A1 protein, partial
NCBI Official Synonym Full Names
solute carrier family 27 (fatty acid transporter), member 1
NCBI Official Symbol
SLC27A1
NCBI Official Synonym Symbols
FATP; FATP1; ACSVL5; FATP-1
NCBI Protein Information
long-chain fatty acid transport protein 1; solute carrier family 27 member 1
UniProt Protein Name
Long-chain fatty acid transport protein 1
UniProt Gene Name
SLC27A1
UniProt Synonym Gene Names
ACSVL5; FATP1; FATP-1; Fatty acid transport protein 1
UniProt Entry Name
S27A1_HUMAN

Uniprot Description

SLC27A1: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Ligase; Mitochondrial; Vesicle; EC 6.2.1.-; Membrane protein, integral; Lipid-binding

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: membrane; endoplasmic reticulum; plasma membrane; integral to membrane

Molecular Function: protein homodimerization activity; fatty acid transporter activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity

Biological Process: cardiolipin biosynthetic process; long-chain fatty acid transport; phosphatidylglycerol biosynthetic process; phosphatidylethanolamine biosynthetic process; long-chain fatty acid metabolic process; cellular lipid metabolic process; phosphatidylserine biosynthetic process; response to insulin stimulus; positive regulation of heat generation; phosphatidylcholine biosynthetic process; phosphatidylinositol biosynthetic process; phosphatidic acid biosynthetic process; adiponectin-mediated signaling pathway; response to cold; medium-chain fatty acid transport; transmembrane transport

Research Articles on SLC27A1

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Product Notes

The SLC27A1 slc27a1 (Catalog #AAA2518442) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC27A1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SLC27A1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1:50-1:200. Researchers should empirically determine the suitability of the SLC27A1 slc27a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC27A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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