Rabbit anti-Human SLC17A3 Polyclonal Antibody | anti-SLC17A3 antibody
SLC17A3 Antibody; HRP conjugated
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]
Uniprot Description
SLC17A3: Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: apical plasma membrane; brush border membrane; cytoplasm; endoplasmic reticulum membrane; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: drug transporter activity; efflux transmembrane transporter activity; organic anion transmembrane transporter activity; sodium-dependent phosphate transmembrane transporter activity; sodium:phosphate symporter activity; toxin transporter activity; urate transmembrane transporter activity; voltage-gated anion channel activity
Biological Process: drug transport; glucose-6-phosphate transport; multidrug transport; organic anion transport; phosphate transport; sodium ion transport; transmembrane transport; urate metabolic process; urate transport
Disease: Uric Acid Concentration, Serum, Quantitative Trait Locus 4
Research Articles on SLC17A3
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Product Notes
The SLC17A3 slc17a3 (Catalog #AAA7001126) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC17A3 Antibody; HRP conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC17A3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the SLC17A3 slc17a3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC17A3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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