Rabbit anti-Human SLC12A7 Polyclonal Antibody | anti-SLC12A7 antibody

SLC12A7 Antibody

Cat. Num. AAA7053381

• Gene Names: SLC12A7; KCC4
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: SLC12A7; Polyclonal Antibody; SLC12A7 Antibody; Solute carrier family 12 member 7; Electroneutral potassium-chloride cotransporter 4; K-Cl cotransporter 4; KCC4; anti-SLC12A7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 1083

• Applicable Applications for anti-SLC12A7 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:20-1:200; IF: 1:50-1:200
• Immunogen: Recombinant Human Solute carrier family 12 member 7 protein (11-117AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7053381 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human heart tissue using MBS7053381 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunofluorescent analysis of A549 cells using MBS7053381 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-SLC12A7 antibody

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 123701900
• NCBI GeneID: 10723
• NCBI Accession #: NP_006589.2
• NCBI GenBank Nucleotide #: NM_006598.2
• UniProt Accession #: Q9Y666; Q4G0F3; Q96I81; Q9H7I3; Q9H7I7; Q9UFW2; A6NDS8
• Molecular Weight: 28,258 Da
• NCBI Official Full Name: solute carrier family 12 member 7
• NCBI Official Synonym Full Names: solute carrier family 12 member 7
• NCBI Official Symbol: SLC12A7
• NCBI Official Synonym Symbols: KCC4
• NCBI Protein Information: solute carrier family 12 member 7
• UniProt Protein Name: Solute carrier family 12 member 7
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC12A7
• UniProt Synonym Gene Names: KCC4

Uniprot Description

KCC4: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification. Belongs to the SLC12A transporter family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: plasma membrane

Molecular Function: potassium ion symporter activity; potassium:chloride symporter activity; protein kinase binding

Biological Process: ion transport; synaptic transmission; transport