Rabbit anti-Human SLAMF6 Polyclonal Antibody | anti-SLAMF6 antibody

SLAMF6 Rabbit pAb

Cat. Num. AAA4757025

• Gene Names: SLAMF6; KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000
• Reactivity: Human
• Applications: Western Blot, Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay, Immunoprecipitation
• Purity: Affinity purified
• Synonyms: SLAMF6; Polyclonal Antibody; SLAMF6 Rabbit pAb; SLAM family member 6; KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000; anti-SLAMF6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes (PubMed:11489943). Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients (PubMed:22184727).
• Purity/Purification: Affinity purified
• Form/Format: Supplied in 50nM Tris-Glycine(pH7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

• Applicable Applications for anti-SLAMF6 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
• Application Notes: WB: 1:1000; ICC/IF: 1:200; FC/FACS: 1:50; IP: 1:20
• Immunogen: Recombinant protein of human SLAMF6
• Conjugation: Unconjugated
• Modification: Unmodified
• Cell Position: Cell membrane, Membrane
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot detection of SLAMF6 in Ramos cell lysates using SLAMF6 Rabbit pAb(1:1000 diluted).Predicted band size:37kDa.Observed band size:60kDa.)

Related Product Information for anti-SLAMF6 antibody

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4+ T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity.
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Product Categories/Family for anti-SLAMF6 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 296040491
• NCBI GeneID: 114836
• NCBI Accession #: NP_001171643.1
• NCBI GenBank Nucleotide #: NM_001184714.1
• UniProt Accession #: Q96DU3; Q14CF0; Q5TAS4; Q5TAS6; Q5TAT3; Q96DV0; A6NMW2; B2R8X8
• Molecular Weight: 24,976 Da
• NCBI Official Full Name: SLAM family member 6 isoform 1
• NCBI Official Synonym Full Names: SLAM family member 6
• NCBI Official Symbol: SLAMF6
• NCBI Official Synonym Symbols: KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000
• NCBI Protein Information: SLAM family member 6; NK-T-B-antigen; NTBA receptor; activating NK receptor; natural killer-, T- and B-cell antigen
• UniProt Protein Name: SLAM family member 6
• Protein Family: SLAM family
• UniProt Gene Name: SLAMF6
• UniProt Synonym Gene Names: KALI; NTB-A
• UniProt Entry Name: SLAF6_HUMAN

NCBI Description

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Uniprot Description

SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: receptor activity