Rabbit SIPA1L2 Polyclonal Antibody | anti-SIPA1L2 antibody

SIPA1L2 Antibody

Cat. Num. AAA150183

• Gene Names: SIPA1L2; SPAL2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: SIPA1L2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: SIPA1L2; Polyclonal Antibody; SIPA1L2 Antibody; SPAL2; KIAA1389; Signal-induced proliferation-associated 1-like protein 2; SIPA1-like protein 2; signal-induced proliferation-associated 1 like 2; anti-SIPA1L2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: SIPA1L2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1722

• Applicable Applications for anti-SIPA1L2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: SIPA1L2 antibody can be used for detection of SIPA1L2 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: SIPA1L2 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human SIPA1L2.
• Buffer: SIPA1L2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: SIPA1L2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SIPA1L2 in rat brain tissue lysate with SIPA1L2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 20 μg/mL.)

Related Product Information for anti-SIPA1L2 antibody

SIPA1L2 Antibody: Signal-induced proliferation associated-like protein 2 (SIPA1L2) is a member of the SIPA1 family of RapGAPs. Little is known of the role of the SIPA1L2 protein, but recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is likely that SIPA1L2 plays a role in embryo development and cell proliferation, possibly including oncogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 112421013
• NCBI GeneID: 57568
• NCBI Accession #: NP_065859
• NCBI GenBank Nucleotide #: NM_020808.3
• UniProt Accession #: Q9P2F8; Q2TV88; Q5VXR7; Q5VXR8; Q641Q4; Q8NA38; Q96DZ3; Q9H9F6
• Molecular Weight: 84,536 Da
• NCBI Official Full Name: signal-induced proliferation-associated 1-like protein 2
• NCBI Official Synonym Full Names: signal-induced proliferation-associated 1 like 2
• NCBI Official Symbol: SIPA1L2
• NCBI Official Synonym Symbols: SPAL2
• NCBI Protein Information: signal-induced proliferation-associated 1-like protein 2; SPA-1-like 2; SIPA1-like protein 2
• UniProt Protein Name: Signal-induced proliferation-associated 1-like protein 2
• Protein Family: Signal-induced proliferation-associated 1-like protein
• UniProt Gene Name: SIPA1L2
• UniProt Synonym Gene Names: KIAA1389; SIPA1-like protein 2
• UniProt Entry Name: SI1L2_HUMAN

Uniprot Description

SIPA1L2: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 1q42.2

Molecular Function: GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; positive regulation of GTPase activity