Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: STAT5A knockout K562 cell lysate; Predicted MW: 91,87kd Observed MW: 91kd Primary Ab: 2ug/ml Rabbit Anti-Human STAT5A Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Signal Transducer And Activator Of Transcription 5A (STAT5A) Polyclonal Antibody | anti-STAT5A antibody
HRP-Linked Polyclonal Antibody to Signal Transducer And Activator Of Transcription 5A (STAT5A)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: STAT5A knockout K562 cell lysate; Predicted MW: 91,87kd Observed MW: 91kd Primary Ab: 2ug/ml Rabbit Anti-Human STAT5A Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: STAT5A knockout K562 cell lysate; Predicted MW: 91,87kd Observed MW: 91kd Primary Ab: 2ug/ml Rabbit Anti-Human STAT5A Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
member of the STAT family of transcription factors; may mediate the biological actions of several interleukin factors (IL2, IL3, IL7) and growth hormones; may be associated with mammary gland function [RGD, Feb 2006]
Uniprot Description
STAT5A: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 10q31
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: DNA binding; double-stranded DNA binding; protein binding; protein phosphatase binding; sequence-specific DNA binding; signal transducer activity; transcription factor activity
Biological Process: 2-oxoglutarate metabolic process; allantoin metabolic process; citrate metabolic process; creatine metabolic process; creatinine metabolic process; cytokine and chemokine mediated signaling pathway; development of secondary female sexual characteristics; development of secondary male sexual characteristics; fatty acid metabolic process; female pregnancy; isoleucine metabolic process; JAK-STAT cascade; lactation; luteinization; mammary gland development; mammary gland involution; natural killer cell differentiation; negative regulation of apoptosis; negative regulation of erythrocyte differentiation; negative regulation of mast cell apoptosis; oxaloacetate metabolic process; peptidyl-tyrosine phosphorylation; Peyer's patch development; positive regulation of activated T cell proliferation; positive regulation of B cell differentiation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of lymphocyte differentiation; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell adhesion; regulation of epithelial cell differentiation; regulation of multicellular organism growth; regulation of steroid metabolic process; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; reproductive process in a multicellular organism; response to ethanol; response to nutrient levels; response to peptide hormone stimulus; sequestering of lipid; succinate metabolic process; T cell differentiation in the thymus; T cell homeostasis; taurine metabolic process; transcription from RNA polymerase II promoter; valine metabolic process
Research Articles on STAT5A
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Product Notes
The STAT5A stat5a (Catalog #AAA2058484) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HRP-Linked Polyclonal Antibody to Signal Transducer And Activator Of Transcription 5A (STAT5A) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Signal Transducer And Activator Of Transcription 5A (STAT5A) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the STAT5A stat5a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Signal Transducer And Activator Of Transcription 5A (STAT5A), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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