Western Blot (WB)
(SH2D1A Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SH2D1A antibody detected the SH2D1A protein (arrow).)
Rabbit anti-Human SH2D1A Polyclonal Antibody | anti-SH2D1A antibody
SH2D1A Antibody (C-term)
Western Blot (WB)
(SH2D1A Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SH2D1A antibody detected the SH2D1A protein (arrow).)
Western Blot (WB)
(SH2D1A Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SH2D1A antibody detected the SH2D1A protein (arrow).)
bidirectional stimulation of T and B cells. This protein contains
an SH2 domain and a short tail. It associates with the signaling
lymphocyte-activation molecule, thereby acting as an inhibitor of
this transmembrane protein by blocking the recruitment of the
SH2-domain-containing signal-transduction molecule SHP-2 to its
docking site. This protein can also bind to other related surface
molecules that are expressed on activated T, B and NK cells,
thereby modifying signal transduction pathways in these cells.
Mutations in this gene cause lymphoproliferative syndrome X-linked
type 1 or Duncan disease, a rare immunodeficiency characterized by
extreme susceptibility to infection with Epstein-Barr virus, with
symptoms including severe mononucleosis and malignant lymphoma.
Multiple transcript variants encoding different isoforms have been
found for this gene.
Snow, A.L., et al. J. Clin. Invest. 119(10):2976-2989(2009)
Nagy, N., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):11966-11971(2009)
Ostrakhovitch, E.A., et al. Cell. Signal. 21(4):540-550(2009)
Schwartzberg, P.L., et al. Nat. Rev. Immunol. 9(1):39-46(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
SH2D1A: Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. Interacts with NTRK1, NTRK2 and NTRK3. Interacts with CD84, CD244, LY9, SLAMF1 and FYN. Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: cytoplasm
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: cell-cell signaling; positive regulation of signal transduction; cellular defense response; positive regulation of natural killer cell mediated cytotoxicity; humoral immune response
Disease: Lymphoproliferative Syndrome, X-linked, 1
Research Articles on SH2D1A
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Product Notes
The SH2D1A sh2d1a (Catalog #AAA9215031) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 85-114. The SH2D1A Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SH2D1A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SH2D1A sh2d1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SH2D1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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