Rabbit anti-Human SGLT-1 Polyclonal Antibody | anti-slc5a11 antibody

SGLT-1 (Sodium Glucose Transporter 1)

Cat. Num. AAA627723

• Gene Names: slc5a11; SGLT-1-like; sglt-1-like-a
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: SGLT-1; Polyclonal Antibody; SGLT-1 (Sodium Glucose Transporter 1); Anti -SGLT-1 (Sodium Glucose Transporter 1); anti-slc5a11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SGLT-1. No significant sequence homology exists with other SGLTs. Species sequence homology (56%): mouse, rat. For mouse and rat, we recommend S1010-86D or S1010-86G.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% BSA.

• Applicable Applications for anti-slc5a11 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 0.5-1ug/ml. Coat ELISA plates at 1ug/ml with control peptide.; Western Blot: 1-10ug/ml using ECL. Detects a band at ~70-77kD.
• Immunogen: Synthetic peptide corresponding to 16aa sequence from the C-terminal, cytoplasmic domain 6 of human SGLT-1 conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-slc5a11 antibody

The kidneys play a major role in the regulation of glucose levels. Kidneys filter approx. 180g of glucose per day from the blood, and this is mostly reabsorbed back into the blood in the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, Sodium glucoseco transporters (SGLT), in the brush-border membrane and then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). At least 3 members of SGLTs (SGLT1-3) have been cloned and characterized from various species. Individual member of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT1-3 genes code for protein of approx 659-672 residues (calculated size of ~75kD). Both N and C-termini are predicted to be extracellualr. There is approx 60-70% homology between SGLT1-3. SGLTs transport a-methyl-D-glucoside (a-MDG), a non-metabolized model substrate, in Na-dependent manner. SGLT1 does not discriminate a-MDG, glucose, and galactose. SGLT2/3 do not transport D-galactose efficiently.

Product Categories/Family for anti-slc5a11 antibody

Antibodies; Abs to Glucose Transporters

NCBI and Uniprot Product Information

• NCBI GI #: 148226148
• NCBI GeneID: 373547
• NCBI Accession #: NP_001079025.1
• NCBI GenBank Nucleotide #: NM_001085556.1
• NCBI Official Full Name: solute carrier family 5 (sodium/inositol cotransporter), member 11
• NCBI Official Synonym Full Names: solute carrier family 5 (sodium/inositol cotransporter), member 11<
• NCBI Official Symbol: slc5a11
• NCBI Official Synonym Symbols: SGLT-1-like; sglt-1-like-a
• NCBI Protein Information: solute carrier family 5 (sodium/inositol cotransporter), member 11; solute carrier family 5 (sodium/inositol cotransporter), member 11; Na+-glucose cotransporter type 1 (SGLT-1)-like protein; solute carrier family 5 (sodium/glucose cotransporter), member 11
• Protein Family: Sodium/myo-inositol cotransporter