Rabbit SGK2 Polyclonal Antibody | anti-SGK2 antibody

Rabbit Polyclonal to Human SGK2

Cat. Num. AAA242578

• Gene Names: SGK2; H-SGK2; dJ138B7.2
• Reactivity: Gibbon, Bovine, Gorilla, Human, Orangutan; Predicted Reactivity: Monkey, Dog, Horse, Rabbit (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: SGK2; Polyclonal Antibody; Rabbit Polyclonal to Human SGK2; Anti-SGK2 Antibody (Kinase Domain) IHC-plus; DJ138B7.2; H-SGK2; Hsgk2; Human SGK2; anti-SGK2 antibody

• Host: Rabbit
• Reactivity: Gibbon, Bovine, Gorilla, Human, Orangutan; Predicted Reactivity: Monkey, Dog, Horse, Rabbit (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human SGK2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SGK3 (67%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 427

• Applicable Applications for anti-SGK2 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA, IHC-P (10 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubat...
• Target Species: Human
• Immunogen Description: Synthetic 15 amino acid peptide from kinase domain of human SGK2. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Bovine (100%); Marmoset, Dog, Horse, Rabbit, Platypus (93%); Bat, Elephant, Panda.
• Immunogen Type: Synthetic peptide
• Immunogen: SGK2 antibody was raised against synthetic 15 amino acid peptide from kinase domain of human SGK2. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Bovine (100%); Marmoset, Dog, Horse, Rabbit, Platypus (93%); Bat, Elephant, Panda, Opossum, Turkey, Chicken (87%); Xenopus (80%).
• Antigen Modification: Kinase Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-SGK2 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-SGK2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-SGK2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-SGK2 antibody

SGK2 is a SGK type protein kinase. Although little is known about the transcriptional regulation of SGK2, the protein has been shown to be phosphorylated and activated by 3-phosphoinositide-dependent protein kinase 1 (PDK1), and to a lesser extent insulin-like growth factor-1, in vitro.

Product Categories/Family for anti-SGK2 antibody

Family: Protein Kinase; Subfamily: SGK

NCBI and Uniprot Product Information

• NCBI GI #: 20127541
• NCBI GeneID: 10110
• NCBI Accession #: NP_057360.2
• NCBI GenBank Nucleotide #: NM_016276.3
• UniProt Accession #: Q9HBY8; Q52PK5; Q5H8Y6; Q5H8Z1; Q5TZR3; Q9UKG6
• Molecular Weight: 43,977 Da
• NCBI Official Full Name: serine/threonine-protein kinase Sgk2 isoform beta
• NCBI Official Synonym Full Names: serum/glucocorticoid regulated kinase 2
• NCBI Official Symbol: SGK2
• NCBI Official Synonym Symbols: H-SGK2; dJ138B7.2
• NCBI Protein Information: serine/threonine-protein kinase Sgk2
• UniProt Protein Name: Serine/threonine-protein kinase Sgk2
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: SGK2
• UniProt Entry Name: SGK2_HUMAN

NCBI Description

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Uniprot Description

SGK2: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser- 416), need to be phsphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; SGK family

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; potassium channel regulator activity; sodium channel regulator activity; ATP binding

Biological Process: positive regulation of transporter activity; regulation of cell growth; response to oxidative stress; transmembrane transport; protein amino acid phosphorylation; regulation of cell proliferation