Rabbit anti-Mouse SGCD Polyclonal Antibody | anti-SGCD antibody

SGCD, CT (SGCD, Delta-sarcoglycan, 35kD dystrophin-associated glycoprotein) (FITC)

Cat. Num. AAA6346837

• Gene Names: SGCD; SGD; DAGD; 35DAG; CMD1L; SGCDP; LGMDR6; SG-delta
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SGCD; Polyclonal Antibody; CT (SGCD; Delta-sarcoglycan; 35kD dystrophin-associated glycoprotein) (FITC); 35kD dystrophin-associated glycoprotein; anti-SGCD antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 289

• Applicable Applications for anti-SGCD antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SGCD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-261 amino acids from the C-terminal region of human SGCD.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SGCD Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SGCD antibody detected the SGCD protein (arrow).)

Related Product Information for anti-SGCD antibody

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Product Categories/Family for anti-SGCD antibody

Antibodies; Carbohydrates; Glycoproteins

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010). Ordonez-Razo, R.M., et al. Genet Test Mol Biomarkers 14(2):237-240(2010). Lin, W.Y., et al. BMC Res Notes 3, 26 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 189571662
• NCBI GeneID: 6444
• NCBI Accession #: NP_001121681.1; NP_000328.2; NP_758447.1
• NCBI GenBank Nucleotide #: NP_001121681.1
• UniProt Accession #: Q92629
• NCBI Official Full Name: delta-sarcoglycan isoform 3
• NCBI Official Synonym Full Names: sarcoglycan delta
• NCBI Official Symbol: SGCD
• NCBI Official Synonym Symbols: SGD; DAGD; 35DAG; CMD1L; SGCDP; LGMDR6; SG-delta
• NCBI Protein Information: delta-sarcoglycan
• UniProt Protein Name: Delta-sarcoglycan
• Protein Family: Delta-sarcoglycan
• UniProt Gene Name: SGCD
• UniProt Synonym Gene Names: Delta-SG; 35DAG
• UniProt Entry Name: SGCD_HUMAN

NCBI Description

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SGCD: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCD are the cause of limb-girdle muscular dystrophy type 2F (LGMD2F). LGMD2F is an autosomal recessive disorder. Defects in SGCD are the cause of cardiomyopathy dilated type 1L (CMD1L). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the sarcoglycan beta/delta/gamma/zeta family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Dystrophin complex

Chromosomal Location of Human Ortholog: 5q33-q34

Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; cytoplasm; integral to membrane; plasma membrane; sarcoglycan complex; sarcolemma

Biological Process: cardiac muscle development; muscle development; heart contraction; muscle cell development

Disease: Muscular Dystrophy, Limb-girdle, Type 2f; Cardiomyopathy, Dilated, 1l