Rabbit anti-Human, Mouse SFTPA1 Polyclonal Antibody | anti-SFTPA1 antibody

SFTPA1 antibody

Cat. Num. AAA9413417

• Gene Names: SFTPA1; SPA; PSAP; PSPA; SP-A; SPA1; PSP-A; SFTP1; SP-A1; COLEC4; SFTPA1B
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: SFTPA1; Polyclonal Antibody; SFTPA1 antibody; SPA; PSAP; PSPA; SP-A; SPA1; PSP-A; SFTP1; SP-A1; COLEC4; SFTPA1B; anti-SFTPA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total SFTPA1 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 263

• Applicable Applications for anti-SFTPA1 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:1000
• Immunogen Type: Peptide
• Immunogen Description: A synthetic peptide of human SFTPA1.
• Target Name: SFTPA1
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using SFTPA1antibody.)

Related Product Information for anti-SFTPA1 antibody

This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants.

Product Categories/Family for anti-SFTPA1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 257467606
• NCBI GeneID: 653509
• NCBI Accession #: NP_001087239.2
• NCBI GenBank Nucleotide #: NM_001093770.2
• UniProt Accession #: Q8IWL2; P07714; Q14DV4; Q5RIR5; Q5RIR7; A8K3T8; B7ZW50; E3VLD8; E3VLD9; E3VLE0; E3VLE1; G5E9J3
• Molecular Weight: 27,736 Da
• NCBI Official Full Name: pulmonary surfactant-associated protein A1 isoform 2
• NCBI Official Synonym Full Names: surfactant protein A1
• NCBI Official Symbol: SFTPA1
• NCBI Official Synonym Symbols: SPA; PSAP; PSPA; SP-A; SPA1; PSP-A; SFTP1; SP-A1; COLEC4; SFTPA1B
• NCBI Protein Information: pulmonary surfactant-associated protein A1
• UniProt Protein Name: Pulmonary surfactant-associated protein A1
• Protein Family: Pulmonary surfactant-associated protein
• UniProt Gene Name: SFTPA1
• UniProt Synonym Gene Names: COLEC4; PSAP; SFTP1; SFTPA; SFTPA1B; PSP-A; PSPA; SP-A; SP-A1
• UniProt Entry Name: SFTA1_HUMAN

NCBI Description

This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Description

SFTPA1B: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Genetic variations in SFTPA1 are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Genetic variations in SFTPA1 are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS); also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB. Belongs to the SFTPA family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen; extracellular region

Molecular Function: lipid transporter activity; carbohydrate binding

Biological Process: respiratory gaseous exchange; lipid transport

Disease: Pulmonary Fibrosis, Idiopathic