Western Blot (WB)
(Western blot analysis of Sestrin-1 antibody (C-term) in mouse heart tissue lysates (35ug/lane). Sestrin-1 (arrow) was detected using the purified Pab.)
Rabbit anti-Human Sestrin-1 Polyclonal Antibody | anti-SESN1 antibody
Sestrin-1, CT (Sestrin 1, p53-regulated Protein PA26, SEST1, PA26, SESN1)
Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.
Western Blot (WB)
(Western blot analysis of Sestrin-1 antibody (C-term) in mouse heart tissue lysates (35ug/lane). Sestrin-1 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of Sestrin-1 antibody (C-term) in mouse heart tissue lysates (35ug/lane). Sestrin-1 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Sestrin-1 Antibody (C-term) western blot analysis in NCI-H460,HL-60 cell line lysates (35ug/lane).This demonstrates the Sestrin-1 antibody detected the Sestrin-1 protein (arrow).)
Western Blot (WB)
(Sestrin-1 Antibody (C-term) western blot analysis in NCI-H460,HL-60 cell line lysates (35ug/lane).This demonstrates the Sestrin-1 antibody detected the Sestrin-1 protein (arrow).)
Flow Cytometry (FC/FACS)
(Sestrin-1 Antibody (C-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(Sestrin-1 Antibody (C-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq]
Uniprot Description
SESN1: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth. Belongs to the sestrin family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: nucleus
Biological Process: negative regulation of cell proliferation; regulation of protein kinase B signaling cascade; cell cycle arrest; response to DNA damage stimulus
Research Articles on SESN1
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Product Notes
The SESN1 (Catalog #AAA625736) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Sestrin-1, CT (Sestrin 1, p53-regulated Protein PA26, SEST1, PA26, SESN1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Sestrin-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Flow Cytometry (FC). Western Blot: 1:1000 Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the SESN1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sestrin-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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