Rabbit anti-Human SERPINB7 Polyclonal Antibody | anti-SERPINB7 antibody

SERPINB7 (Serpin B7, Megsin, TP55, DKFZp686D06190, MGC120014, MGC120015) (FITC)

Cat. Num. AAA6393775

• Gene Names: SERPINB7; PPKN; TP55; MEGSIN
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SERPINB7; Polyclonal Antibody; SERPINB7 (Serpin B7; Megsin; TP55; DKFZp686D06190; MGC120014; MGC120015) (FITC); anti-SERPINB7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SERPINB7.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-SERPINB7 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human SERPINB7, aa1-380 (NP_003775.1).
• Immunogen Sequence: MASLAAANAEFCFNLFREMDDNQGNGNVFFSSLSLFAALALVRLGAQDDSLSQIDKLLHVNTASGYGNSSNSQSGLQSQLKRVFSDINASHKDYDLSIVNGLFAEKVYGFHKDYIECAEKLYDAKVERVDFTNHLEDTRRNINKWVENETHGKIKNVIGEGGISSSAVMVLVNAVYFKGKWQSAFTKSETINCHFKSPKCSGKAVAMMHQERKFNLSVIEDPSMKILELRYNGGINMYVLLPENDLSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIEKNYEMKQYLRALGLKDIFDESKADLSGIASGGRLYISRMMHKSYIEVTEEGTEATAATGSNIVEKQLPQSTLFRADHPFLFVIRKDDIILFSGKVSCP
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SERPINB7 expression in transfected 293T cell line by SERPINB7 polyclonal antibody. Lane 1: SERPINB7 transfected lysate (42.9kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-SERPINB7 antibody

SERPINB7 might function as an inhibitor of Lys-specific proteases and might influence the maturation of megakaryocytes via its action as a serpin.

Product Categories/Family for anti-SERPINB7 antibody

Antibodies; Protease Inhibitors

NCBI and Uniprot Product Information

• NCBI GI #: 4505149
• NCBI GeneID: 8710
• NCBI Accession #: NP_003775.1
• NCBI GenBank Nucleotide #: NM_003784.2
• UniProt Accession #: O75635; Q1ED45; Q3KPG4; B4DUW8; F5GZC0
• Molecular Weight: 41,174 Da
• NCBI Official Full Name: serpin B7 isoform 1
• NCBI Official Synonym Full Names: serpin family B member 7
• NCBI Official Symbol: SERPINB7
• NCBI Official Synonym Symbols: PPKN; TP55; MEGSIN
• NCBI Protein Information: serpin B7
• UniProt Protein Name: Serpin B7
• Protein Family: Serpin
• UniProt Gene Name: SERPINB7
• UniProt Entry Name: SPB7_HUMAN

NCBI Description

This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Uniprot Description

SERPINB7: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. Belongs to the serpin family. Ov-serpin subfamily.

Chromosomal Location of Human Ortholog: 18q21.33

Cellular Component: extracellular space; cytoplasm

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: positive regulation of transforming growth factor-beta1 production; positive regulation of collagen biosynthetic process

Disease: Palmoplantar Keratoderma, Nagashima Type