Rabbit anti-Human SERPINB7 Polyclonal Antibody | anti-SERPINB7 antibody

SERPINB7, ID (Serpin B7, Megsin, TP55) (Azide free) (HRP)

Cat. Num. AAA6498993

• Gene Names: SERPINB7; PPKN; TP55; MEGSIN
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: SERPINB7; Polyclonal Antibody; ID (Serpin B7; Megsin; TP55) (Azide free) (HRP); anti-SERPINB7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SERPINB7.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-SERPINB7 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 108-137 in the central region of human SERPINB7, UniProt Accession #O75635.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of HL-60 cell line lysates (35ug/lane) using MBS627197. SERPINB7 (arrow) was detected using MBS627197.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human kidney carcinoma using MBS627197, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.)

Related Product Information for anti-SERPINB7 antibody

SERPINB7 might function as an inhibitor of Lys-specific proteases and might influence the maturation of megakaryocytes via its action as a serpin.

Product Categories/Family for anti-SERPINB7 antibody

Antibodies; Protease Inhibitors

References

1. Maixnerova, D., et.al., Folia Biol. (Praha) 54(2), 40-45 (2008). 2. Wang, Z.H., et.al., Zhonghua Yi Xue Za Zhi 86(19), 1337-1341 (2006). 3. Inagi, R., et.al., J. Am. Soc. Nephrol. 13(11), 2715-2722 (2002).

NCBI and Uniprot Product Information

• NCBI GI #: 4505149
• NCBI GeneID: 8710
• NCBI Accession #: NP_003775.1
• NCBI GenBank Nucleotide #: NM_003784.3
• UniProt Accession #: O75635; Q1ED45; Q3KPG4; B4DUW8; F5GZC0
• Molecular Weight: 41,174 Da
• NCBI Official Full Name: serpin B7 isoform 1
• NCBI Official Synonym Full Names: serpin family B member 7
• NCBI Official Symbol: SERPINB7
• NCBI Official Synonym Symbols: PPKN; TP55; MEGSIN
• NCBI Protein Information: serpin B7
• UniProt Protein Name: Serpin B7
• Protein Family: Serpin
• UniProt Gene Name: SERPINB7
• UniProt Entry Name: SPB7_HUMAN

NCBI Description

This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Uniprot Description

SERPINB7: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. Belongs to the serpin family. Ov-serpin subfamily.

Chromosomal Location of Human Ortholog: 18q21.33

Cellular Component: extracellular space; cytoplasm

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: positive regulation of transforming growth factor-beta1 production; positive regulation of collagen biosynthetic process

Disease: Palmoplantar Keratoderma, Nagashima Type