Rabbit Serotonin receptor 5HT1A Polyclonal Antibody | anti-Htr1a antibody

Serotonin receptor 5HT1A polyclonal antibody

Cat. Num. AAA565842

• Gene Names: Htr1a; Gpcr18
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Peptide Affinity purified
• Synonyms: Serotonin receptor 5HT1A; Polyclonal Antibody; Serotonin receptor 5HT1A polyclonal antibody; anti-Htr1a antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Peptide Affinity purified
• Form/Format: Liquid. In PBS containing 50% glycerol and 0.01% sodium azide

• Applicable Applications for anti-Htr1a antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
• Immunogen: Synthetic peptide corresponding to the sequence near the N-terminus of mouse serotonin receptor 5HT_1A
• Preparation and Storage: For long term storage, store at -20 degree C; Shipping: Shipped on Blue Ice

Related Product Information for anti-Htr1a antibody

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine found in the central nervous system, gastrointestinal tract, and blood with broad physiological functions as a neurotransmitter, in gastric motility, hemostasis, and cardiovascular integrity. Seven subclasses (5-HT 1-7) of serotonin receptors have been identified, a majority of which are members of the seven transmembrane domain-containing G-protein coupled receptor (GPCR) family, and are the target of several anti-depressant drugs. The 5-HT1 subclass consists of five highly homologous receptors that couple via G(i/o) alpha subunits to inhibit adenylyl cyclase activity. The 5-HT1A receptor gene is 99% homologous between human and mouse, and is expressed from an intronless gene with a predicted length of 421 amino acids. 5-HT1A receptor activation is generally inhibitory to cAMP production, but may also stimulate type II adenylyl cyclase activity in a cell-specific manner via release of G(beta/gamma) subunits when coupled to G(i2). 5-HT1A expression in mammals is strongest in CNS limbic pathways that control emotion, including tissue of the hippocampus, dorsal raphé, and septum.

Product Categories/Family for anti-Htr1a antibody

Cellular Analysis; Cell Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 31542972
• NCBI GeneID: 15550
• NCBI Accession #: NP_032334.2
• NCBI GenBank Nucleotide #: NM_008308.4
• UniProt Accession #: Q64264; Q60956; Q61617; Q8BGS4
• Molecular Weight: 46,176 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 1A
• NCBI Official Synonym Full Names: 5-hydroxytryptamine (serotonin) receptor 1A
• NCBI Official Symbol: Htr1a
• NCBI Official Synonym Symbols: Gpcr18
• NCBI Protein Information: 5-hydroxytryptamine receptor 1A
• UniProt Protein Name: 5-hydroxytryptamine receptor 1A
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: Htr1a
• UniProt Synonym Gene Names: Gpcr18; 5-HT-1A; 5-HT1A

Uniprot Description

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.