Rabbit Serotonin Receptor 1B Polyclonal Antibody | anti-HTR1B antibody

Serotonin Receptor 1B (5-Hydroxytryptamine (Serotonin) Receptor 1B, 5-Hydroxytryptamine Receptor 1B, 5-HT-1B, 5-HT-1D-beta, 5-HT1B, 5-HT1B Receptor, 5-HT1DB, HTR1B, HTR1D2, HTR1DB, S12, Serotonin 1D beta Receptor)

Cat. Num. AAA621995

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Serotonin Receptor 1B; Polyclonal Antibody; Serotonin Receptor 1B (5-Hydroxytryptamine (Serotonin) Receptor 1B; 5-Hydroxytryptamine Receptor 1B; 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1B Receptor; 5-HT1DB; HTR1B; HTR1D2; HTR1DB; S12; Serotonin 1D beta Receptor); Anti -Serotonin Receptor 1B (5-Hydroxytryptamine (Serotonin) Receptor 1B; anti-HTR1B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: A 40-41kD band is detected. Species Crossreactivity: Human, Mouse, Rat
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

• Applicable Applications for anti-HTR1B antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: This antibody was generated by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 8-26 and 263-278 of rat 5-HT1BR (Accession number P28564) (6).
• Positive Control: human, mouse, or rat brain
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-HTR1B antibody

Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1). Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase (2). Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum (3,4). The in situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei (5).

Product Categories/Family for anti-HTR1B antibody

Antibodies; Abs to Serotonin Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 37221615
• NCBI GeneID: 403741
• UniProt Accession #: P79250; Q6VVV0
• Molecular Weight: 42,930 Da
• NCBI Official Full Name: serotonin receptor 1B
• NCBI Official Symbol: HTR1B
• NCBI Protein Information: 5-hydroxytryptamine receptor 1B; 5-HT1B; 5-HT-1B; 5-HTR1B; 5-HT1D beta; 5-HT1D subtype beta; serotonin receptor 1B; 5-Hydroxytryptamine 1D receptor subtype beta
• UniProt Protein Name: 5-hydroxytryptamine receptor 1B
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: HTR1B
• UniProt Entry Name: 5HT1B_CANFA

Uniprot Description

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Post-translational modification: Phosphorylated

By similarity.Palmitoylated

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.