Rabbit anti-Human HTR1B Polyclonal Antibody | anti-HTR1B antibody

HTR1B, ID (HTR1B, HTR1DB, 5-hydroxytryptamine receptor 1B, S12, Serotonin 1D beta receptor, Serotonin receptor 1B) (PE)

Cat. Num. AAA6308814

• Gene Names: HTR1B; S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT1DB
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HTR1B; Polyclonal Antibody; ID (HTR1B; HTR1DB; 5-hydroxytryptamine receptor 1B; S12; Serotonin 1D beta receptor; Serotonin receptor 1B) (PE); Serotonin receptor 1B; anti-HTR1B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-HTR1B antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: HTR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-253 amino acids from the Central region of human HTR1B.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(HTR1B Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the HTR1B antibody detected the HTR1B protein (arrow).)

Related Product Information for anti-HTR1B antibody

The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.

Product Categories/Family for anti-HTR1B antibody

Antibodies; Receptors

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Kiezebrink, K., et al. World J. Biol. Psychiatry 11(6):824-833(2010). Mekli, K., et al. Eur Neuropsychopharmacol (2010). In press: Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010): Cross, D.S., et al. BMC Genet. 11, 51 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 4504533
• NCBI GeneID: 3351
• NCBI Accession #: NP_000854.1
• NCBI GenBank Nucleotide #: NM_000863.1
• UniProt Accession #: P28222; Q4VAY7
• Molecular Weight: 43,568 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 1B
• NCBI Official Synonym Full Names: 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
• NCBI Official Symbol: HTR1B
• NCBI Official Synonym Symbols: S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT1DB
• NCBI Protein Information: 5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT-1D-beta; serotonin receptor 1B; serotonin 1D beta receptor
• UniProt Protein Name: 5-hydroxytryptamine receptor 1B
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: HTR1B
• UniProt Synonym Gene Names: HTR1DB; 5-HT-1B; 5-HT1B
• UniProt Entry Name: 5HT1B_HUMAN

NCBI Description

The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]

Uniprot Description

5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: serotonin binding; serotonin receptor activity; drug binding

Biological Process: vasoconstriction; drinking behavior; negative regulation of synaptic transmission, glutamatergic; response to mineralocorticoid stimulus; bone remodeling; response to cocaine; regulation of dopamine secretion; negative regulation of serotonin secretion; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cAMP biosynthetic process; response to ethanol; serotonin receptor, adenylate cyclase inhibiting pathway; G-protein coupled receptor internalization; protein kinase C activation; negative regulation of synaptic transmission, GABAergic; regulation of behavior