Western Blot (WB)
(Western blot analysis of lysate from human brain tissue lysate, using SEPT5 Antibody (N-term). MBS9212249 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.)
Rabbit SEPT5 Polyclonal Antibody | anti-SEPT5 antibody
SEPT5 Antibody (N-term)
Western Blot (WB)
(Western blot analysis of lysate from human brain tissue lysate, using SEPT5 Antibody (N-term). MBS9212249 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.)
Western Blot (WB)
(Western blot analysis of lysate from human brain tissue lysate, using SEPT5 Antibody (N-term). MBS9212249 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.)
Immunohistochemistry (IHC)
(SEPT5 Antibody (N-term) (MBS9212249)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEPT5 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(SEPT5 Antibody (N-term) (MBS9212249)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEPT5 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
nucleotide binding proteins, originally described in yeast as cell
division cycle regulatory proteins. Septins are highly conserved in
yeast, Drosophila, and mouse and appear to regulate cytoskeletal
organization. Disruption of septin function disturbs cytokinesis
and results in large multinucleate or polyploid cells. This gene is
mapped to 22q11, the region frequently deleted in DiGeorge and
velocardiofacial syndromes. A translocation involving the MLL gene
and this gene has also been reported in patients with acute myeloid
leukemia. Alternative splicing results in multiple transcript
variants. The presence of a non-consensus polyA signal (AACAAT) in
this gene also results in read-through transcription into the
downstream neighboring gene (GP1BB; platelet glycoprotein Ib),
whereby larger, non-coding transcripts are produced. [provided by
RefSeq].
Amin, N.D., et al. J. Neurosci. 28(14):3631-3643(2008)
Xin, X., et al. J. Histochem. Cytochem. 55(11):1089-1094(2007)
Blaser, S., et al. J. Pathol. 210(1):103-110(2006)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]
Uniprot Description
SEPT5: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion. Belongs to the septin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Cell cycle regulation; Cytoskeletal; Hydrolase
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: synaptic vesicle; cytoskeleton; plasma membrane; terminal button; cell cortex
Molecular Function: GTPase activity; protein binding; GTP binding; structural molecule activity
Biological Process: regulation of exocytosis; metabolic process; cytokinesis; synaptic vesicle targeting
Research Articles on SEPT5
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Product Notes
The SEPT5 sept5 (Catalog #AAA9212249) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The SEPT5 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's SEPT5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). WB~~1:1000. Researchers should empirically determine the suitability of the SEPT5 sept5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEPT5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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