Western Blot (WB)
(Western blot (WB) analysis of ZAC polyclonal antibody at 1:500 dilutionLaneA: Hela whole cell lysateLaneB: U-87MG whole cell lysateLaneC: PC12 whole cell lysateLaneD: CT26 whole cell lysate)
Rabbit ZAC Polyclonal Antibody | anti-ZAC antibody
ZAC polyclonal antibody
IHC: 1:50~1:200
Western Blot (WB)
(Western blot (WB) analysis of ZAC polyclonal antibody at 1:500 dilutionLaneA: Hela whole cell lysateLaneB: U-87MG whole cell lysateLaneC: PC12 whole cell lysateLaneD: CT26 whole cell lysate)
Western Blot (WB)
(Western blot (WB) analysis of ZAC polyclonal antibody at 1:500 dilutionLaneA: Hela whole cell lysateLaneB: U-87MG whole cell lysateLaneC: PC12 whole cell lysateLaneD: CT26 whole cell lysate)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010]
Uniprot Description
PLAGL1: Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 6q24-q25
Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; nucleus
Molecular Function: DNA binding; metal ion binding
Biological Process: transcription from RNA polymerase II promoter; apoptosis; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; cell cycle arrest
Disease: Diabetes Mellitus, Transient Neonatal, 1
Research Articles on ZAC
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Product Notes
The ZAC plagl1 (Catalog #AAA3014946) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZAC polyclonal antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ZAC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500~1:1000 IHC: 1:50~1:200. Researchers should empirically determine the suitability of the ZAC plagl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZAC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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