Rabbit anti-Human SEPP1 Polyclonal Antibody | anti-SEPP1 antibody

SEPP1, ID (SEPP1, SELP, Selenoprotein P)

Cat. Num. AAA6004723

• Gene Names: SEPP1; SeP; SELP
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: SEPP1; Polyclonal Antibody; ID (SEPP1; SELP; Selenoprotein P); Anti -SEPP1; anti-SEPP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-SEPP1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: SEPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-262 amino acids from the Central region of human SEPP1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SEPP1 Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the SEPP1 antibody detected the SEPP1 protein (arrow).)

Related Product Information for anti-SEPP1 antibody

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.

Product Categories/Family for anti-SEPP1 antibody

Antibodies; Abs to Selenoprotein

NCBI and Uniprot Product Information

• NCBI GI #: 148277022
• NCBI GeneID: 6414
• NCBI Accession #: NP_001087195.1
• NCBI GenBank Nucleotide #: NM_001093726.1
• UniProt Accession #: P49908; Q6PD59; Q6PI43; Q6PI87; Q6PJF9
• Molecular Weight: 43,174 Da
• NCBI Official Full Name: selenoprotein P isoform 2
• NCBI Official Synonym Full Names: selenoprotein P, plasma, 1
• NCBI Official Symbol: SEPP1
• NCBI Official Synonym Symbols: SeP; SELP
• NCBI Protein Information: selenoprotein P
• UniProt Protein Name: Selenoprotein P
• Protein Family: Selenoprotein
• UniProt Gene Name: SEPP1
• UniProt Synonym Gene Names: SELP; SeP
• UniProt Entry Name: SEPP1_HUMAN

NCBI Description

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SEPP1: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis. Belongs to the selenoprotein P family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular space; extracellular region

Molecular Function: selenium binding

Biological Process: sexual reproduction; locomotory behavior; response to oxidative stress; brain development; selenium metabolic process; growth; post-embryonic development