Immunohistochemistry (IHC)
(SEPN1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEPN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human SEPN1 Polyclonal Antibody | anti-SEPN1 antibody
SEPN1 Antibody (C-term)
WB~~1:1000
Immunohistochemistry (IHC)
(SEPN1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEPN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(SEPN1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEPN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Western Blot (WB)
(SEPN1 Antibody (C-term) western blot analysis in Hela,HepG2 cell line lysates (35ug/lane).This demonstrates the SEPN1 antibody detected the SEPN1 protein (arrow).)
Western Blot (WB)
(SEPN1 Antibody (C-term) western blot analysis in Hela,HepG2 cell line lysates (35ug/lane).This demonstrates the SEPN1 antibody detected the SEPN1 protein (arrow).)
selenocysteine (Sec) residue at its active site. The selenocysteine
is encoded by the UGA codon that normally signals translation
termination. The 3' UTR of selenoprotein genes have a common
stem-loop structure, the sec insertion sequence (SECIS), that is
necessary for the recognition of UGA as a Sec codon rather than as
a stop signal. Mutations in this gene cause the classical phenotype
of multiminicore disease and congenital muscular dystrophy with
spinal rigidity and restrictive respiratory syndrome. Two
alternatively spliced transcript variants encoding distinct
isoforms have been found for this gene.
Maiti, B., et al. Hum. Mutat. 30(3):411-416(2009)
Jurynec, M.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(34):12485-12490(2008)
Lin, L., et al. PLoS Genet. 4 (10), E1000225 (2008) :
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
SEPN1: Defects in SEPN1 are the cause of rigid spine muscular dystrophy 1 (RSMD1). A neuromuscular disorder characterized by poor axial muscle strength, scoliosis and neck weakness, and a variable degree of spinal rigidity. Early ventilatory insufficiency can lead to death by respiratory failure. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: endoplasmic reticulum membrane
Molecular Function: protein binding; calcium ion binding
Disease: Rigid Spine Muscular Dystrophy 1
Research Articles on SEPN1
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Product Notes
The SEPN1 sepn1 (Catalog #AAA9207585) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 417-445. The SEPN1 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SEPN1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). IHC~~1:10~50 WB~~1:1000. Researchers should empirically determine the suitability of the SEPN1 sepn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEPN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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