Rabbit anti-Human SEPN1 Polyclonal Antibody | anti-SEPN1 antibody

SEPN1 Antibody

Cat. Num. AAA9405053

• Gene Names: SEPN1; RSS; CFTD; SELN; MDRS1; RSMD1
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: SEPN1; Polyclonal Antibody; SEPN1 Antibody; RSS; CFTD; SELN; MDRS1; RSMD1; anti-SEPN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total SEPN1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 590

• Applicable Applications for anti-SEPN1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human selenoprotein N, 1
• Target Name: SEPN1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/20.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using at dilution 1/20.)

Related Product Information for anti-SEPN1 antibody

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Product Categories/Family for anti-SEPN1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 47578099
• NCBI GeneID: 57190
• NCBI Accession #: NP_065184.2
• NCBI GenBank Nucleotide #: NM_020451.2
• UniProt Accession #: Q9NZV5; Q6PI70; Q969F6; Q9NUI6; A6NJG8; A8MQ64
• Molecular Weight: 62,034 Da
• NCBI Official Full Name: selenoprotein N isoform 1
• NCBI Official Synonym Full Names: selenoprotein N, 1
• NCBI Official Symbol: SEPN1
• NCBI Official Synonym Symbols: RSS; CFTD; SELN; MDRS1; RSMD1
• NCBI Protein Information: selenoprotein N
• UniProt Protein Name: Selenoprotein N
• Protein Family: Selenoprotein
• UniProt Gene Name: SEPN1
• UniProt Synonym Gene Names: SELN; SelN
• UniProt Entry Name: SELN_HUMAN

NCBI Description

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SEPN1: Defects in SEPN1 are the cause of rigid spine muscular dystrophy 1 (RSMD1). A neuromuscular disorder characterized by poor axial muscle strength, scoliosis and neck weakness, and a variable degree of spinal rigidity. Early ventilatory insufficiency can lead to death by respiratory failure. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: endoplasmic reticulum membrane

Molecular Function: protein binding; calcium ion binding

Disease: Rigid Spine Muscular Dystrophy 1