Rabbit anti-Human, Mouse SENP5 Polyclonal Antibody | anti-SENP5 antibody

SENP5 Antibody

Cat. Num. AAA9504763

• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: SENP5; Polyclonal Antibody; SENP5 Antibody; anti-SENP5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: SENP5 Antibody detects endogenous levels of total SENP5 protein.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 709

• Applicable Applications for anti-SENP5 antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; IHC: 1:50~1:100; ELISA: 1:20000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human SENP5.
• Immunogen Range: 651-700
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SENP5 Antibody. The picture on the right is blocked with the synthesized peptide.)

Western Blot (WB)

(Western blot analysis of lysates from COS7 cells, using SENP5 Antibody. The lane on the right is blocked with the synthesized peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 808688298
• NCBI GeneID: 205564
• NCBI Accession #: NP_001294974.1
• NCBI GenBank Nucleotide #: NM_001308045.1
• UniProt Accession #: Q96HI0; Q96SA5; B4DY82
• Molecular Weight: 86 kDa
• NCBI Official Full Name: sentrin-specific protease 5 isoform 2
• NCBI Official Synonym Full Names: SUMO1/sentrin specific peptidase 5
• NCBI Official Symbol: SENP5
• NCBI Protein Information: sentrin-specific protease 5
• UniProt Protein Name: Sentrin-specific protease 5
• Protein Family: Sentrin-specific protease
• UniProt Gene Name: SENP5

NCBI Description

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

Uniprot Description

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.