Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue)
Rabbit anti-Human Semaphorin 3C (SEMA3C) Polyclonal Antibody | anti-SEMA3C antibody
Polyclonal Antibody to Semaphorin 3C (SEMA3C)
Immunohistochemistry: 5-20 Ug/mL;1:17-70
Immunocytochemistry: 5-20 Ug/mL;1:17-70
Optimal working dilutions must be determined by end user.
Store at 4ºC for frequent use.
Aliquot and store at -20ºC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Human Tissue)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
Uniprot Description
SEMA3C: a secreted protein that may be involved in cell survival mechanisms. Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain. Binds with high affinity to the receptor NRP2.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7q21.11
Cellular Component: extracellular space
Molecular Function: semaphorin receptor binding
Biological Process: axon guidance; blood vessel remodeling; immune response; limb bud formation; negative chemotaxis; neural crest cell migration; neural tube development; post-embryonic development; response to drug; somitogenesis
Research Articles on SEMA3C
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Product Notes
The SEMA3C sema3c (Catalog #AAA2001984) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Semaphorin 3C (SEMA3C) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Semaphorin 3C (SEMA3C) can be used in a range of immunoassay formats including, but not limited to, WB; IHC; ICC; IP. Western blotting: 0.5-2 Ug/mL;1:170-700Immunohistochemistry: 5-20 Ug/mL;1:17-70
Immunocytochemistry: 5-20 Ug/mL;1:17-70 Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the SEMA3C sema3c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Semaphorin 3C (SEMA3C), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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