Rabbit SELENOF Polyclonal Antibody | anti-SELENOF antibody

SELENOF Rabbit pAb

Cat. Num. AAA4760211

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: SELENOF; Polyclonal Antibody; SELENOF Rabbit pAb; selenoprotein F; SEP15; anti-SELENOF antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 1.2mg/ml (varies by lot)

• Applicable Applications for anti-SELENOF antibody: Western Blot (WB)
• Application Notes: WB: 1:1000-1:5000
• Immunogen: Fusion protein of human SELENOF
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western Blot analysis of SELENOF in Rat liver tissue lysate using SELENOF Rabbit pAb at dilution 1/1000)

Related Product Information for anti-SELENOF antibody

The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 42741648
• NCBI GeneID: 9403
• NCBI Accession #: NP_004252.2
• NCBI GenBank Nucleotide #: NM_004261.3
• UniProt Accession #: O60613; Q4GZG7; Q8WU00; Q9BS64; Q9GZW0; Q9NR01
• Molecular Weight: 13,219 Da
• NCBI Official Full Name: 15 kDa selenoprotein isoform 1
• NCBI Official Symbol: SEP15
• NCBI Protein Information: 15 kDa selenoprotein
• UniProt Protein Name: 15 kDa selenoprotein
• UniProt Gene Name: SEP15
• UniProt Entry Name: SEP15_HUMAN

NCBI Description

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies in mouse suggest that this selenoprotein may have redox function and may be involved in the quality control of protein folding. This gene is localized on chromosome 1p31, a genetic locus commonly mutated or deleted in human cancers. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SEP15: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum. Belongs to the selenoprotein M/SEP15 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: endoplasmic reticulum lumen

Molecular Function: selenium binding

Biological Process: 'de novo' posttranslational protein folding