Rabbit SEC31A Polyclonal Antibody | anti-SEC31A antibody
SEC31A Antibody
Gene Names
SEC31A; ABP125; ABP130; HSPC275; HSPC334; SEC31L1
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SEC31A; Polyclonal Antibody; SEC31A Antibody; 1810024J13Rik; ABP125; ABP130; AU042160; DKFZp686N07171; HSPC275; HSPC334; KIAA0905; MGC90305; MGC93320; Protein transport protein Sec31A; SEC31 homolog A (S. cerevisiae); SEC31 like 1; SEC31 like protein 1; SEC31 related protein A; SEC31L1; VAP1; Web1 like protein; Yeast Sec31p homolog; anti-SEC31A antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
SEC31A Antibody detects endogenous levels of SEC31A.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SEC31A antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human SEC31A.
Conjugation
Unconjugated
Similarity
The ALG-2-binding site motif-2 (ABS-2) contains a PXPGF sequence that binds hydrophobic pocket 3 of PDCD6. Belongs to the WD repeat SEC31 family.
Post Translational Modifications
Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.
Subunit Structure
COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with PDCD6; interaction takes place in response to cytosolic calcium increase and leads to bridge together the BCR(KLHL12) complex and SEC31A, leading to monoubiquitination. Interacts with KLHL12.
Tissue Specificity
Abundantly and ubiquitously expressed.
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Note
Associates with membranes in a GTP-dependent manner (By similarity). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882, PubMed:28442536, PubMed:17428803).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-SEC31A antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
127,556 Da
NCBI Official Full Name
protein transport protein Sec31A isoform 4
NCBI Official Synonym Full Names
SEC31 homolog A (S. cerevisiae)
NCBI Official Symbol
SEC31A
NCBI Official Synonym Symbols
ABP125; ABP130; HSPC275; HSPC334; SEC31L1
NCBI Protein Information
protein transport protein Sec31A; SEC31-like protein 1; SEC31-related protein A; web1-like protein; yeast Sec31p homolog
UniProt Protein Name
Protein transport protein Sec31A
Protein Family
UniProt Gene Name
SEC31A
UniProt Synonym Gene Names
KIAA0905; SEC31L1
UniProt Entry Name
SC31A_HUMAN
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Product Notes
The SEC31A sec31a (Catalog #AAA9631241) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SEC31A Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SEC31A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SEC31A sec31a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEC31A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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