Rabbit anti-Human SCNM1, NT Polyclonal Antibody | anti-SCNM1 antibody
Anti-SCNM1, NT (Sodium Channel Modifier 1, SCNM1)
Gene Names
SCNM1; MGC3180
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Purified
Synonyms
SCNM1; NT; Polyclonal Antibody; Anti-SCNM1; NT (Sodium Channel Modifier 1; SCNM1); Sodium Channel Modifier 1; anti-SCNM1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human SCNM1.
Purity/Purification
Purified
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Concentration
~0.25mg/ml (varies by lot)
Applicable Applications for anti-SCNM1 antibody
ELISA; Western Blot
Application Notes
Recommended Dilutions: ELISA: 1:1,000
Western Blot: 1:100-1:500
Western Blot: 1:100-1:500
Immunogen
Synthetic peptide selected from the N-terminal region of human SCNM1 (KLH).
Source Information
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Shipping Temperature: Blue Ice
Shipping Temperature: Blue Ice
Related Product Information for anti-SCNM1 antibody
SCNM1 is a zinc finger protein and putative splicing factor that modifies phenotypic expression of Scn8a mutations in mouse models. Phylogenetic comparison of zinc finger sequences placed SCNM1 within the U1C subfamily of RNA binding proteins that are commonly found in RNA-processing proteins. The SCNM1 protein is localized exclusively to the nucleus. Mutations in the mouse Scn8a gene cause inherited movement disorders that range in severity from tremor to ataxia, dystonia, and juvenile lethality. The severity of the hypomorphic allele Scn8a(medJ) is determined by the unlinked modifier gene Scnm1. The modifier mutation, R187X, is characteristic of strain C57BL/6J and reduces the abundance of correctly spliced sodium channel transcripts below the threshold for survival. Mice with the Scn8a(medJ) mutation on any strain except C57BL/6J have 10% of Scn8a transcript correctly spliced and develop a progressive disorder with dystonia and ataxia but live longer than 1.5 years. The same mutation on a C57BL/6J background results in only 5% of correctly spliced transcript, leading to paralysis and survival less than one month.
Product Categories/Family for anti-SCNM1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,949 Da
NCBI Official Full Name
sodium channel modifier 1 isoform 2
NCBI Official Synonym Full Names
sodium channel modifier 1
NCBI Official Symbol
SCNM1
NCBI Official Synonym Symbols
MGC3180
NCBI Protein Information
sodium channel modifier 1; OTTHUMP00000014151; OTTHUMP00000014262
UniProt Protein Name
Sodium channel modifier 1
Protein Family
UniProt Gene Name
SCNM1
UniProt Entry Name
SCNM1_HUMAN
Similar Products
Product Notes
The SCNM1 scnm1 (Catalog #AAA626230) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SCNM1, NT (Sodium Channel Modifier 1, SCNM1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SCNM1, NT can be used in a range of immunoassay formats including, but not limited to, ELISA; Western Blot. Recommended Dilutions: ELISA: 1:1,000 Western Blot: 1:100-1:500. Researchers should empirically determine the suitability of the SCNM1 scnm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCNM1, NT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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