Western Blot (WB)
(Western blot analysis of SCN3B expression in A549 (A), mouse liver (B) whole cell lysates.)
Rabbit anti-Human, Mouse SCN3B Polyclonal Antibody | anti-SCN3B antibody
Anti-SCN3B Antibody
Western Blot (WB)
(Western blot analysis of SCN3B expression in A549 (A), mouse liver (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of SCN3B expression in A549 (A), mouse liver (B) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
SCN3B: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN3B are the cause of Brugada syndrome type 7 (BRGDA7). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
Protein type: Membrane protein, integral; Channel, sodium
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: voltage-gated sodium channel complex; plasma membrane; integral to membrane; Z disc
Molecular Function: sodium channel regulator activity; voltage-gated sodium channel activity
Biological Process: membrane depolarization; nervous system development; sodium ion transport; positive regulation of heart rate; sensory perception of pain; cardiac muscle contraction
Disease: Brugada Syndrome 7
Research Articles on SCN3B
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Product Notes
The SCN3B scn3b (Catalog #AAA8308035) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SCN3B Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SCN3B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the SCN3B scn3b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCN3B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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