Rabbit anti-Human, Rat SCN2A Polyclonal Antibody | anti-SCN2A antibody

SCN2A Conjugated Antibody

Cat. Num. AAA9447675

• Gene Names: SCN11A; NaN; SNS-2; NAV1.9; SCN12A
• Reactivity: Human, Rat
• Applications: Most Applications
• Synonyms: SCN2A; Polyclonal Antibody; SCN2A Conjugated Antibody; HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na (v)1.2; anti-SCN2A antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total SCN2A protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-SCN2A antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human sodium channel, voltage-gated, type II, alpha subunit
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-SCN2A antibody

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 115583667
• NCBI GeneID: 11280
• NCBI Accession #: NP_054858.2
• NCBI GenBank Nucleotide #: NM_014139.2
• UniProt Accession #: Q99250; Q68K15; Q8NDX3; Q9UHE0; Q9UHM0; A6NN05; C9JD48; C9JR31; Q9UI33
• Molecular Weight: 204,922 Da
• NCBI Official Full Name: sodium channel protein type 11 subunit alpha
• NCBI Official Synonym Full Names: sodium channel, voltage-gated, type XI, alpha subunit
• NCBI Official Symbol: SCN11A
• NCBI Official Synonym Symbols: NaN; SNS-2; NAV1.9; SCN12A
• NCBI Protein Information: sodium channel protein type 11 subunit alpha; PN5; hNaN; sensory neuron sodium channel 2; peripheral nerve sodium channel 5; voltage-gated sodium channel Nav1.9; sodium channel protein type XI subunit alpha; voltage-gated sodium channel subunit alpha Nav1
• UniProt Protein Name: Sodium channel protein type 2 subunit alpha
• Protein Family: Sodium channel protein
• UniProt Gene Name: SCN2A
• UniProt Synonym Gene Names: NAC2; SCN2A1; SCN2A2
• UniProt Entry Name: SCN2A_HUMAN

NCBI Description

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]