Rabbit anti-Human SCARF2 Polyclonal Antibody | anti-SCARF2 antibody

SCARF2 polyclonal antibody

Cat. Num. AAA3000772

• Gene Names: SCARF2; NSR1; SREC2; VDEGS; SREC-II; SRECRP-1
• Reactivity: Human
• Applications: Immunohistochemistry, Immunofluorescence, ELISA
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: SCARF2; Polyclonal Antibody; SCARF2 polyclonal antibody; SREC2; SREPCR; Scavenger receptor class F member 2; SRECRP-1; Scavenger receptor expressed by endothelial cells 2 protein; SREC-II; anti-SCARF2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: SREC-II Polyclonal Antibody detects endogenous levels of SREC-II protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applicable Applications for anti-SCARF2 antibody: Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)(paraffin section), ELISA (EIA)
• Application Notes: IHC: 1/100-1/300; ELISA: 1/40,000
• Immunogen: The antiserum was produced against synthesized peptide derived from human SCARF2. AA range: 677-726
• Preparation and Storage: Store at 4 degee C for short term. Aliquot and store at -20 degee C long term. Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using SCARF2 Antibody. The picture on the right is blocked with the synthesized peptide.)

Related Product Information for anti-SCARF2 antibody

Background: scavenger receptor class F member 2(SCARF2) Homo sapiens. The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

NCBI and Uniprot Product Information

• NCBI GI #: 24586659
• NCBI GeneID: 91179
• NCBI Accession #: NP_699165.2
• NCBI GenBank Nucleotide #: NM_153334.4
• UniProt Accession #: Q96GP6; Q58A83; Q8IXF3; Q9BW74; E5RFB8
• Molecular Weight: 92,479 Da
• NCBI Official Full Name: scavenger receptor class F member 2 isoform 1
• NCBI Official Synonym Full Names: scavenger receptor class F, member 2
• NCBI Official Symbol: SCARF2
• NCBI Official Synonym Symbols: NSR1; SREC2; VDEGS; SREC-II; SRECRP-1
• NCBI Protein Information: scavenger receptor class F member 2; scavenger receptor expressed by endothelial cells 2 protein
• UniProt Protein Name: Scavenger receptor class F member 2
• Protein Family: Scavenger receptor
• UniProt Gene Name: SCARF2
• UniProt Synonym Gene Names: SREC2; SREPCR; SREC-II
• UniProt Entry Name: SREC2_HUMAN

NCBI Description

The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

SREC-II: Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Defects in SCARF2 are the cause of Van den Ende-Gupta syndrome (VDEGS). A syndrome characterized by craniofacial and skeletal abnormalities that include blepharophimosis, a flat and wide nasal bridge, narrow and beaked nose, hypoplastic maxilla with or without cleft palate and everted lower lip, prominent ears, down-slanting eyes, arachnodactyly, and camptodactyly. Patients present congenital joint contractures that improve without intervention, and normal growth and development. Intelligence is normal. Rarely, enlarged cerebella can be present. Some patients experience respiratory problems due to laryngeal abnormalities. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: focal adhesion; integral to membrane

Molecular Function: protein binding; scavenger receptor activity

Biological Process: heterophilic cell adhesion; receptor-mediated endocytosis

Disease: Van Den Ende-gupta Syndrome