Rabbit anti-Human, Mouse SATB1 Polyclonal Antibody | anti-SATB1 antibody

SATB1 antibody (pAb)

Cat. Num. AAA388601

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purified
• Synonyms: SATB1; Polyclonal Antibody; SATB1 antibody (pAb); Special AT-Rich Sequence Binding Protein 1; anti-SATB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: Purified IgG in 70mM Tris (pH8), 105mM NaCl, 31mM glycine, 0.07mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.

• Applicable Applications for anti-SATB1 antibody: Western Blot (WB)
• Application Notes: Applications Validated:; WB: 1:500-1:2,000 dilution
• Immunogen: This SATB1 antibody was raised against a peptide within the N-terminal region of SATB1.
• Preparation and Storage: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20 degree C for up to 2 years. Keep all reagents on ice when not in storage.1ug/ul

Western Blot (WB)

(SATB1 antibody (pAb) tested by Western blot. Whole cell extract of mouse thymus cells (30 ug per lane) probed with SATB1 antibody (pAb) (1:2,000 dilution).)

Related Product Information for anti-SATB1 antibody

Short Description: Our SATB1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot; it has been shown to react with Human and Mouse samples.

Background: SATB1 (Special AT-rich sequence-binding protein 1) is a chromosome-associated protein that binds to matrix attachment regions (MARs) of DNA at special AT-rich sequences and induces local chromatin-loop remodeling. SATB1 functions as both a chromatin organizer and transcription factor. It regulates gene expression and higher-order chromatin structure of multigene clusters. SATB1 acts as a docking site for several chromatin remodeling enzymes and recruits corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. It is required for the switching of fetal globin genes, plays a role in chromatin organization and nuclear architecture during apoptosis. It is a crucial factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis. SATB1 contributes to metastatic potential in breast cancer cells, directly upregulating metastasis-associated genes while downregulating tumor-suppressor genes. It is also required for the differentiation of embryonic stem cells through repression of ES pluripotency factors Nanog, Klf4, and Tbx3.

Product Categories/Family for anti-SATB1 antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 196114999
• NCBI GeneID: 6304
• NCBI Accession #: NP_001124482; AB_2793363
• NCBI GenBank Nucleotide #: NM_001131010
• UniProt Accession #: B3KXF1; Q59EQ0; C9JTR6; Q01826
• Molecular Weight: 89,127 Da
• NCBI Official Full Name: DNA-binding protein SATB1 isoform 1
• NCBI Official Synonym Full Names: SATB homeobox 1
• NCBI Official Symbol: SATB1
• NCBI Protein Information: DNA-binding protein SATB1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA); special AT-rich sequence-binding protein 1
• UniProt Protein Name: DNA-binding protein SATB1
• Protein Family: DNA-binding protein
• UniProt Gene Name: SATB1
• UniProt Entry Name: SATB1_HUMAN