Rabbit anti-Human S39A8 Polyclonal Antibody | anti-S39A8 antibody

S39A8, ID (SLC39A8, BIGM103, ZIP8, Zinc transporter ZIP8, BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, Solute carrier family 39 member 8, Zrt-and Irt-like protein 8) (FITC)

Cat. Num. AAA6344769

• Gene Names: SLC39A8; ZIP8; PP3105; BIGM103; LZT-Hs6
• Reactivity: Human
• Applications: Western Blot, Flow Cytometry, Functional Assay
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: S39A8; Polyclonal Antibody; ID (SLC39A8; BIGM103; ZIP8; Zinc transporter ZIP8; BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; Solute carrier family 39 member 8; Zrt-and Irt-like protein 8) (FITC); SLC39A8; Zrt-and Irt-like protein 8; anti-S39A8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human S39A8.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-S39A8 antibody: Western Blot (WB), Flow Cytometry (FC/FACS), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 218-246 in the central region of human S39A8.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in CEM cell line lysates (35ug/lane), usingMBS6005119. S39A8 (arrow) was detected usingMBS6005119.)

Flow Cytometry (FC/FACS)

(Flow Cytometric analysis of CEM cells using MBS6005119 (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-S39A8 antibody

S39A8 encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke.

Product Categories/Family for anti-S39A8 antibody

Antibodies; Transport Proteins

References

1. Wang, L. Cancer Epidemiol. Biomarkers Prev. 17 (12), 3558-3566 (2008). 2. Aiba, I. Mol. Pharmacol. 74 (3), 823-833 (2008). 3. Besecker, B. Am. J. Physiol. Lung Cell Mol. Physiol. 294 (6), L1127-L1136 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 205830403
• NCBI GeneID: 64116
• NCBI Accession #: NP_071437
• NCBI GenBank Nucleotide #: NM_001135146.1
• UniProt Accession #: Q9C0K1; Q96SM9; Q9BVC0; Q9NSA4; B4E2H3
• Molecular Weight: 48,089 Da
• NCBI Official Full Name: zinc transporter ZIP8 isoform a
• NCBI Official Synonym Full Names: solute carrier family 39 (zinc transporter), member 8
• NCBI Official Symbol: SLC39A8
• NCBI Official Synonym Symbols: ZIP8; PP3105; BIGM103; LZT-Hs6
• NCBI Protein Information: zinc transporter ZIP8; ZIP-8; Zrt- and Irt-like protein 8; solute carrier family 39 member 8; LIV-1 subfamily of ZIP zinc transporter 6; BCG induced integral membrane protein BIGM103; solute carrier family 39 (metal ion transporter), member 8; BCG-induced
• UniProt Protein Name: Zinc transporter ZIP8
• UniProt Gene Name: SLC39A8
• UniProt Synonym Gene Names: BIGM103; ZIP8; LZT-Hs6; ZIP-8
• UniProt Entry Name: S39A8_HUMAN

NCBI Description

This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

Uniprot Description

SLC39A8: Acts as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: plasma membrane; integral to membrane

Molecular Function: metal ion transmembrane transporter activity

Biological Process: zinc ion transport; transmembrane transport