Rabbit anti-Human S1PR2 Polyclonal Antibody | anti-S1PR2 antibody

S1PR2, CT (S1PR2, EDG5, Sphingosine 1-phosphate receptor 2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5) (Biotin)

Cat. Num. AAA6344702

• Gene Names: S1PR2; EDG5; H218; LPB2; S1P2; AGR16; EDG-5; Gpcr13
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: S1PR2; Polyclonal Antibody; CT (S1PR2; EDG5; Sphingosine 1-phosphate receptor 2; Endothelial differentiation G-protein coupled receptor 5; Sphingosine 1-phosphate receptor Edg-5) (Biotin); Sphingosine 1-phosphate receptor Edg-5; anti-S1PR2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-S1PR2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: S1PR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 271-298 amino acids selected from the C-terminal region of human S1PR2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(S1PR2 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the S1PR2 antibody detected the S1PR2 protein (arrow).)

Related Product Information for anti-S1PR2 antibody

This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation

Product Categories/Family for anti-S1PR2 antibody

Antibodies; G Protein Receptors

References

Oskeritzian, C.A., et al. J. Exp. Med. 207(3):465-474(2010). McGeachie, M., et al. Circulation 120(24):2448-2454(2009). Cattoretti, G., et al. Cancer Res. 69(22):8686-8692(2009). Randriamboavonjy, V., et al. Basic Res. Cardiol. 104(3):333-340(2009). Li, M.H., et al. Mol. Cancer Res. 6(10):1649-1656(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 134244587
• NCBI GeneID: 9294
• NCBI Accession #: NP_004221.3
• NCBI GenBank Nucleotide #: NM_004230.3
• UniProt Accession #: O95136; Q86UN8
• Molecular Weight: 38,867 Da
• NCBI Official Full Name: sphingosine 1-phosphate receptor 2
• NCBI Official Synonym Full Names: sphingosine-1-phosphate receptor 2
• NCBI Official Symbol: S1PR2
• NCBI Official Synonym Symbols: EDG5; H218; LPB2; S1P2; AGR16; EDG-5; Gpcr13
• NCBI Protein Information: sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P receptor EDG5; S1P receptor Edg-5; sphingosine 1-phosphate receptor Edg-5; endothelial differentiation G-protein coupled receptor 5; endothelial differentiation, sphingolipid G-protein-coupled recept
• UniProt Protein Name: Sphingosine 1-phosphate receptor 2
• Protein Family: Sphingosine 1-phosphate receptor
• UniProt Gene Name: S1PR2
• UniProt Synonym Gene Names: EDG5; S1P receptor 2; S1P2
• UniProt Entry Name: S1PR2_HUMAN

NCBI Description

This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation [provided by RefSeq, Jul 2008]

Uniprot Description

EDG5: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Lipid-binding; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: integrin binding; G-protein coupled receptor activity; G-protein-coupled receptor binding; lipid binding

Biological Process: G-protein coupled receptor protein signaling pathway; activation of MAPK activity; positive regulation of cell proliferation