S100 alpha 6 Polyclonal Antibody | anti-S100 alpha 6 antibody

Anti-S100 alpha 6 Antibody

Cat. Num. AAA178057

• Gene Names: S100A6; 2A9; PRA; 5B10; CABP; CACY
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen Affinity Purified
• Synonyms: S100 alpha 6; Polyclonal Antibody; Anti-S100 alpha 6 Antibody; Protein S100-A6; 2A9; 5B10; CABP; CACY; Calcyclin; Growth factor inducible protein 2A9; Growth factor-inducible protein 2A9; MLN 4; MLN4; OTTHUMP00000015472; OTTHUMP00000015473; PRA; PRAGrowth factor inducible protein 2A9; Prolactin receptor associated protein; Prolactin receptor-associated protein; Protein S100 A6; S100 A6; S100 calcium binding protein A6 (calcyclin); S100 calcium binding protein A6; S100 calcium-binding protein A6; S100A6; S10A6_HUMAN; anti-S100 alpha 6 antibody

• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 90

• Applicable Applications for anti-S100 alpha 6 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Application Notes: Western Blot Concentration: 0.1-0.5ug/ml; Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
• Immunogen: E Coli-derived human S100 alpha 6 recombinant protein (Position: M1-G90). Human S100 alpha 6 shares 96.6% and 95.5% amino acid (aa) sequence identity with mouse and rat S100 alpha 6, respectively.
• Ig Type: Rabbit IgG
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti- S100 alpha 6 Picoband antibody, MBS178057, Western blottingAll lanes: Anti S100 alpha 6 (MBS178057) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: A431 Whole Cell Lysate at 40ugPredicted bind size: 10KDObserved bind size: 10KD)

Immunohistochemistry (IHC)

(Anti- S100 alpha 6 Picoband antibody, MBS178057, IHC(P)IHC(P): Mouse Testis Tissue )

Immunohistochemistry (IHC)

(Anti- S100 alpha 6 Picoband antibody, MBS178057, IHC(P)IHC(P): Rat Lung Tissue)

Immunohistochemistry (IHC)

(Anti- S100 alpha 6 Picoband antibody, MBS178057, IHC(P)IHC(P): Human Mammary Cancer Tissue )

Immunohistochemistry (IHC)

(Anti- S100 alpha 6 Picoband antibody, MBS178057, IHC(P)IHC(P): Human Placenta Tissue )

Related Product Information for anti-S100 alpha 6 antibody

Description: Rabbit IgG polyclonal antibody for Protein S100-A6(S100A6) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Background: S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. And S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.

References

1. "Entrez Gene: S100A6 S100 calcium binding protein A6". 2. Sofiadis A, Dinets A, Orre LM, Branca RM, Juhlin CC, Foukakis T, Wallin G, Höög A, Hulchiy M, Zedenius J, Larsson C, Lehtiö J (October 2010). "Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma". Thyroid 20 (10): 1067-76.

NCBI and Uniprot Product Information

• NCBI GI #: 7657532
• NCBI GeneID: 6277
• NCBI Accession #: NP_055439.1
• NCBI GenBank Nucleotide #: NM_014624.3
• UniProt Accession #: P06703; Q5RHS4; D3DV39
• Molecular Weight: 10,180 Da
• NCBI Official Full Name: protein S100-A6
• NCBI Official Synonym Full Names: S100 calcium binding protein A6
• NCBI Official Symbol: S100A6
• NCBI Official Synonym Symbols: 2A9; PRA; 5B10; CABP; CACY
• NCBI Protein Information: protein S100-A6
• UniProt Protein Name: Protein S100-A6
• UniProt Gene Name: S100A6
• UniProt Synonym Gene Names: CACY; PRA
• UniProt Entry Name: S10A6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]

Uniprot Description

S100A6: May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. Belongs to the S-100 family.

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nuclear envelope; nucleus; perinuclear region of cytoplasm; ruffle

Molecular Function: calcium ion binding; calcium-dependent protein binding; ion transmembrane transporter activity; protein binding; protein homodimerization activity; tropomyosin binding; zinc ion binding

Biological Process: axonogenesis; positive regulation of fibroblast proliferation; signal transduction