Western Blot (WB)
(GRXCR1 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the GRXCR1 antibody detected the GRXCR1 protein (arrow).)
Rabbit anti-Mouse GRXCR1 Polyclonal Antibody | anti-GRXCR1 antibody
GRXCR1 Antibody (Center)
Western Blot (WB)
(GRXCR1 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the GRXCR1 antibody detected the GRXCR1 protein (arrow).)
Western Blot (WB)
(GRXCR1 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the GRXCR1 antibody detected the GRXCR1 protein (arrow).)
autosomal-recessive nonsyndromic hearing impairment. This gene
encodes a protein which contains GRX-like domains; these domains
play a role in the S-glutathionylation of proteins and may be
involved in actin organization in hair cells.
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
NCBI and Uniprot Product Information
NCBI Description
This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010]
Uniprot Description
GRXCR1: May play a role in actin filament architecture in developing stereocilia of sensory cells. Defects in GRXCR1 are the cause of deafness autosomal recessive type 25 (DFNB25). DFNB25 is characterized by moderate to severe or profound hearing loss which is progressive in some individuals but not in others. Speech development is impaired in some but not all affected individuals and vestibular dysfunction is observed in some affected individuals. Belongs to the GRXCR1 family.
Chromosomal Location of Human Ortholog: 4p13
Cellular Component: stereocilium
Molecular Function: electron carrier activity; protein disulfide oxidoreductase activity
Biological Process: inner ear receptor stereocilium organization and biogenesis; sensory perception of sound; cell redox homeostasis; inner ear receptor cell development; auditory receptor cell differentiation; vestibular receptor cell development; post-embryonic organ morphogenesis
Disease: Deafness, Autosomal Recessive 25
Research Articles on GRXCR1
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Product Notes
The GRXCR1 grxcr1 (Catalog #AAA9203129) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 83-112. The GRXCR1 Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GRXCR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the GRXCR1 grxcr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRXCR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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