Immunohistochemistry (IHC)
(Anti-RTN4 / Nogo antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Rabbit RTN4 / Nogo Polyclonal Antibody | anti-RTN4 antibody
Rabbit Polyclonal to Human RTN4 / Nogo
Predicted Reactivity: Bovine (at least 90% immunogen sequence identity)
Predicted Reactivity: Bovine (at least 90% immunogen sequence identity)
Usage: This antibody recognizes Nogo-A (approximately 220 kD)and Nogo-B2 and B1 (approximately 50 kD and 48 kD in human and 43 kD and 41 kD in mouse and rat, respectively).
Immunohistochemistry (IHC)
(Anti-RTN4 / Nogo antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Immunohistochemistry (IHC)
(Anti-RTN4 / Nogo antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Western Blot (WB)
(Western blot of Nogo-A and -B in A) human, B) mouse, and C) rat brain tissue lysate using antibody at 1:2000.)
Western Blot (WB)
(Western blot of Nogo-A and -B in A) human, B) mouse, and C) rat brain tissue lysate using antibody at 1:2000.)
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
Nogo: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass; Inhibitor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p16.3
Cellular Component: cell projection; cell soma; endoplasmic reticulum; plasma membrane; integral to endoplasmic reticulum membrane; nuclear envelope; intracellular
Molecular Function: protein binding
Biological Process: regulation of apoptosis; nerve growth factor receptor signaling pathway; apoptosis; cerebral cortex radial glia guided migration; axonal fasciculation; negative regulation of axonogenesis; negative regulation of axon extension; angiogenesis; negative regulation of cell growth; regulation of axonogenesis; regulation of cell migration
Research Articles on RTN4
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Product Notes
The RTN4 rtn4 (Catalog #AAA243907) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human RTN4 / Nogo reacts with Gibbon, Human, Monkey, Mouse, Pig, Rat Predicted Reactivity: Bovine (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's RTN4 / Nogo can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB). IHC-P (1:100), WB (1:500 - 1:2000) Usage: This antibody recognizes Nogo-A (approximately 220 kD)and Nogo-B2 and B1 (approximately 50 kD and 48 kD in human and 43 kD and 41 kD in mouse and rat, respectively). Researchers should empirically determine the suitability of the RTN4 rtn4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RTN4 / Nogo, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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