Western Blot (WB)
(RTN2 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the RTN2 antibody detected the RTN2 protein (arrow).)
Rabbit anti-Human RTN2 Polyclonal Antibody | anti-RTN2 antibody
RTN2, NT (RTN2, NSPL1, Reticulon-2, Neuroendocrine-specific protein-like 1, Neuroendocrine-specific protein-like I)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(RTN2 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the RTN2 antibody detected the RTN2 protein (arrow).)
Western Blot (WB)
(RTN2 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the RTN2 antibody detected the RTN2 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]
Uniprot Description
RTN2: Defects in RTN2 are the cause of spastic paraplegia autosomal dominant type 12 (SPG12). A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: endoplasmic reticulum; T-tubule; integral to endoplasmic reticulum membrane
Molecular Function: protein binding
Biological Process: intracellular protein transport across a membrane; regulation of glucose import
Disease: Spastic Paraplegia 12, Autosomal Dominant
Research Articles on RTN2
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Product Notes
The RTN2 rtn2 (Catalog #AAA6012517) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RTN2, NT (RTN2, NSPL1, Reticulon-2, Neuroendocrine-specific protein-like 1, Neuroendocrine-specific protein-like I) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RTN2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the RTN2 rtn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RTN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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