Western Blot (WB)
(The anti-MSK2 Pab is used in Western blot to detect MSK2 in placenta tissue lysate. Indirect immunofluorescence analysis showed that MSK2 is predominantly localized in the nucleus of parental (10T1/2) and oncogene-transformed (Ciras-3) mouse fibroblasts. Cells were co-stained with DAPI to visualize nucleus compartment. Data is kindly provided by B. Drobic and Dr. J. Davie from University of Manitoba (Winnipeg, Canada).)
Rabbit anti-Human, mouse RSKB (MSK2) Polyclonal Antibody | anti-RPS6KA4 antibody
RSKB (MSK2) Antibody (C-term R321)
Western Blot (WB)
(The anti-MSK2 Pab is used in Western blot to detect MSK2 in placenta tissue lysate. Indirect immunofluorescence analysis showed that MSK2 is predominantly localized in the nucleus of parental (10T1/2) and oncogene-transformed (Ciras-3) mouse fibroblasts. Cells were co-stained with DAPI to visualize nucleus compartment. Data is kindly provided by B. Drobic and Dr. J. Davie from University of Manitoba (Winnipeg, Canada).)
Western Blot (WB)
(The anti-MSK2 Pab is used in Western blot to detect MSK2 in placenta tissue lysate. Indirect immunofluorescence analysis showed that MSK2 is predominantly localized in the nucleus of parental (10T1/2) and oncogene-transformed (Ciras-3) mouse fibroblasts. Cells were co-stained with DAPI to visualize nucleus compartment. Data is kindly provided by B. Drobic and Dr. J. Davie from University of Manitoba (Winnipeg, Canada).)
The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).
Pierrat, B., et al., J. Biol. Chem. 273(45):29661-29671 (1998).
Deak, M., et al., EMBO J. 17(15):4426-4441 (1998).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
MSK2: an AGC kinase of the RSK family. Has two kinase domains connected by a regulatory linker region. Phosphorylates H3 and HMG-14 in response to growth factors and cellular stress.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; AGC group; RSK family; MSK subfamily
Chromosomal Location of Human Ortholog: 11q11-q13
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; mitogen-activated protein kinase p38 binding; magnesium ion binding; ribosomal protein S6 kinase activity; ATP binding
Biological Process: axon guidance; regulation of transcription, DNA-dependent; positive regulation of histone phosphorylation; histone phosphorylation; negative regulation of cytokine production; activation of CREB transcription factor; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; inflammatory response; protein amino acid phosphorylation; activation of NF-kappaB transcription factor
Research Articles on RPS6KA4
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Product Notes
The RPS6KA4 rps6ka4 (Catalog #AAA9209293) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 322-354. The RSKB (MSK2) Antibody (C-term R321) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's RSKB (MSK2) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the RPS6KA4 rps6ka4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RSKB (MSK2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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