Rabbit RRM2 Polyclonal Antibody | anti-RRM2 antibody

RRM2 Rabbit Polyclonal

Cat. Num. AAA7603729

• Gene Names: RRM2; R2; RR2; RR2M
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RRM2; Polyclonal Antibody; RRM2 Rabbit Polyclonal; anti-RRM2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 449

• Applicable Applications for anti-RRM2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Ribonucleotide reductase M2 polypeptide
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using MBS7603729 (RRM2 Antibody) at dilution of 1:50)

Western Blot (WB)

(K-562 cells were subjected to SDS PAGE followed by western blot with MBS7603729 (RRM2 antibody) at dilution of 1:200)

NCBI and Uniprot Product Information

• NCBI GI #: 260064013
• NCBI GeneID: 6241
• NCBI Accession #: NP_001159403.1
• NCBI GenBank Nucleotide #: NM_001165931.1
• Molecular Weight: 51,093 Da
• NCBI Official Full Name: ribonucleoside-diphosphate reductase subunit M2 isoform 1
• NCBI Official Synonym Full Names: ribonucleotide reductase regulatory subunit M2
• NCBI Official Symbol: RRM2
• NCBI Official Synonym Symbols: R2; RR2; RR2M
• NCBI Protein Information: ribonucleoside-diphosphate reductase subunit M2
• UniProt Protein Name: Ribonucleoside-diphosphate reductase subunit M2
• Protein Family: Ribonucleoside-diphosphate reductase
• UniProt Gene Name: RRM2
• UniProt Synonym Gene Names: RR2
• UniProt Entry Name: RIR2_HUMAN

NCBI Description

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

Uniprot Description

RRM2: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family.

Protein type: Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Oxidoreductase; Other Amino Acids Metabolism - glutathione; EC 1.17.4.1

Chromosomal Location of Human Ortholog: 2p25-p24

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; ribonucleoside-diphosphate reductase complex

Molecular Function: metal ion binding; protein binding; ribonucleoside-diphosphate reductase activity

Biological Process: deoxyribonucleoside diphosphate metabolic process; deoxyribonucleotide biosynthetic process; DNA replication; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; nucleobase, nucleoside and nucleotide interconversion; protein heterotetramerization