Rabbit NEK6 Polyclonal Antibody | anti-NEK6 antibody

Rabbit Polyclonal to Human NEK6

Cat. Num. AAA243861

• Gene Names: NEK6; SID6-1512
• Reactivity: Gibbon, Gorilla, Human, Monkey, Orangutan
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: NEK6; Polyclonal Antibody; Rabbit Polyclonal to Human NEK6; Anti-NEK6 Antibody (N-Terminus) IHC-plus; NIMA-related kinase 6; Protein kinase SID6-1512; NimA-related protein kinase 6; SID6-1512; Human NEK6; anti-NEK6 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human, Monkey, Orangutan
• Clonality: Polyclonal
• Specificity: Human NEK6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 313

• Applicable Applications for anti-NEK6 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubat...
• Target Species: Human
• Immunogen Description: Synthetic 14 amino acid peptide from N-terminus of human NEK6. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Hamster, Panda, Dog, Horse, Pig (86%).
• Immunogen Type: Synthetic peptide
• Immunogen: NEK6 antibody was raised against synthetic 14 amino acid peptide from N-terminus of human NEK6. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Hamster, Panda, Dog, Horse, Pig (86%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-NEK6 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NEK6 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NEK6 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NEK6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NEK6 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-NEK6 antibody

NEK6 encodes a NEK type protein kinase, which contains a C-terminal NIMA-like catalytic domain. The protein is believed to regulate chromatin condensation in mammalian cells via phosphorylation of histones H1 and H3, and it has been shown to phosphorylate ribosomal S6 protein kinase (S6K1) and serum and glucocorticoid induced protein kinase (SGK1), which regulate diverse cellular processes.

Product Categories/Family for anti-NEK6 antibody

Family: Protein Kinase; Subfamily: NEK

NCBI and Uniprot Product Information

• NCBI GI #: 19923407
• NCBI GeneID: 10783
• NCBI Accession #: NP_055212.2
• NCBI GenBank Nucleotide #: NM_014397.5
• UniProt Accession #: Q9HC98; Q5TBG3; Q5TBG9; Q6FG86; Q6IAR3; Q96E83; Q9ULX2; B7Z2D9
• Molecular Weight: 38,460 Da
• NCBI Official Full Name: serine/threonine-protein kinase Nek6 isoform 2
• NCBI Official Synonym Full Names: NIMA-related kinase 6
• NCBI Official Symbol: NEK6
• NCBI Official Synonym Symbols: SID6-1512
• NCBI Protein Information: serine/threonine-protein kinase Nek6; protein kinase SID6-1512; nimA-related protein kinase 6; never in mitosis A-related kinase 6; putative serine-threonine protein kinase; NIMA (never in mitosis gene a)-related kinase 6
• UniProt Protein Name: Serine/threonine-protein kinase Nek6
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: NEK6
• UniProt Synonym Gene Names: NimA-related protein kinase 6
• UniProt Entry Name: NEK6_HUMAN

NCBI Description

The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

NEK6: a protein kinase of the NEK family. Important in mitosis. May regulate spindle function.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Other group; NEK family

Chromosomal Location of Human Ortholog: 9q33.3-q34.11

Cellular Component: spindle pole; microtubule; cytoplasm; microtubule organizing center; nuclear speck; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; signal transducer activity; kinesin binding; magnesium ion binding; protein kinase binding; ATP binding

Biological Process: mitosis; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; protein amino acid autophosphorylation; regulation of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; mitotic nuclear envelope disassembly; cytokinesis; spindle assembly; mitotic cell cycle; signal transduction; G2/M transition DNA damage checkpoint; protein amino acid phosphorylation; chromosome segregation