Rabbit anti-Human RPH3AL Polyclonal Antibody | anti-RPH3AL antibody

RPH3AL Rabbit Polyclonal

Cat. Num. AAA7603639

• Gene Names: RPH3AL; NOC2
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RPH3AL; Polyclonal Antibody; RPH3AL Rabbit Polyclonal; anti-RPH3AL antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 286

• Applicable Applications for anti-RPH3AL antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Immunogen: Rabphilin 3A-like (without C2 domains)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human stomach using MBS7603639 (RPH3AL antibody) at dilution of 1:100)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7603639 (RPH3AL antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 298676512
• NCBI GeneID: 9501
• NCBI Accession #: NP_001177341.1
• NCBI GenBank Nucleotide #: NM_001190412.1
• Molecular Weight: 31,190 Da
• NCBI Official Full Name: rab effector Noc2 isoform 2
• NCBI Official Synonym Full Names: rabphilin 3A-like (without C2 domains)
• NCBI Official Symbol: RPH3AL
• NCBI Official Synonym Symbols: NOC2
• NCBI Protein Information: rab effector Noc2
• UniProt Protein Name: Rab effector Noc2
• Protein Family: Rab effector
• UniProt Gene Name: RPH3AL
• UniProt Synonym Gene Names: NOC2
• UniProt Entry Name: RPH3L_HUMAN

NCBI Description

The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]

Uniprot Description

RPH3AL: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Acts as a potential RAB3B effector protein in epithelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cytoplasm; plasma membrane; secretory granule membrane

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; cytoskeletal protein binding; LIM domain binding; protein binding; Rab GTPase binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; exocytosis; glucose homeostasis; intracellular protein transport; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of protein secretion; regulation of calcium ion-dependent exocytosis; response to drug; vesicle fusion