Rab effector Noc2 Recombinant Protein | RPH3AL recombinant protein

Recombinant Human Rab effector Noc2

Cat. Num. AAA1282122

• Gene Names: RPH3AL; NOC2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Rab effector Noc2; Recombinant Human Rab effector Noc2; No C2 domains protein; Rabphilin-3A-like protein; RPH3AL recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-315aa; Full Length
• Sequence: MADTIFGSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRKQHLSPAEVEAILQVIQRAERLDVLEQQRIGRLVERLETMRRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPTEPAEREPRSSETSRIYTWARGRVVSSDSDSDSDLSSSSLEDRLPSTGVRDRKGDKPWKESGGSVEAPRMGFTHPPGHLSGCQSSLASGETGTGSADPPGGPRPGLTRRAPVKDTPGRAPAADAAPAGPSSCLG
• Sequence Length: 315

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for RPH3AL recombinant protein

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Acts as a potential RAB3B effector protein in epithelial cells. 1 Publication

Product Categories/Family for RPH3AL recombinant protein

Cell Cycle

References

Cloning of a human ortholog (RPH3AL) of (RNO) Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus.Smith J.S., Tachibana I., Allen C., Chiappa S.A., Lee H.K., McIver B., Jenkins R.B., Raffel C.Genomics 59:97-101(1999) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004)

NCBI and Uniprot Product Information

• NCBI GI #: 298676510
• NCBI GeneID: 9501
• NCBI Accession #: NP_001177340.1
• NCBI GenBank Nucleotide #: NM_001190411.1
• UniProt Accession #: Q9UNE2; Q9BSB3; D3DTG7
• Molecular Weight: 50.5 kDa
• NCBI Official Full Name: rab effector Noc2 isoform 1
• NCBI Official Synonym Full Names: rabphilin 3A-like (without C2 domains)
• NCBI Official Symbol: RPH3AL
• NCBI Official Synonym Symbols: NOC2
• NCBI Protein Information: rab effector Noc2
• UniProt Protein Name: Rab effector Noc2
• Protein Family: Rab effector
• UniProt Gene Name: RPH3AL
• UniProt Synonym Gene Names: NOC2
• UniProt Entry Name: RPH3L_HUMAN

NCBI Description

The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]

Uniprot Description

RPH3AL: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Acts as a potential RAB3B effector protein in epithelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cytoplasm; secretory granule membrane

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; cytoskeletal protein binding; LIM domain binding; protein binding; Rab GTPase binding; syntaxin binding

Biological Process: exocytosis; glucose homeostasis; intracellular protein transport; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of protein secretion; regulation of calcium ion-dependent exocytosis; response to drug