Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer using RPA2 Polyclonal Antibody at dilution of 1/45)
Rabbit anti-Human RPA2 Polyclonal Antibody | anti-RPA2 antibody
RPA2 Polyclonal Antibody
IHC: 1:30-150
WB: 1:500-2000
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer using RPA2 Polyclonal Antibody at dilution of 1/45)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer using RPA2 Polyclonal Antibody at dilution of 1/45)
Western Blot (WB)
(Western Blot analysis of Hela, huvec, HepG2, A549, Jurkat, 231 and A431 cells using RPA2 Polyclonal Antibody at dilution of 1/650)
Western Blot (WB)
(Western Blot analysis of Hela, huvec, HepG2, A549, Jurkat, 231 and A431 cells using RPA2 Polyclonal Antibody at dilution of 1/650)
NCBI and Uniprot Product Information
Uniprot Description
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Research Articles on RPA2
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Product Notes
The RPA2 rpa2 (Catalog #AAA2542411) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RPA2 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RPA2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:2000-5000 IHC: 1:30-150 WB: 1:500-2000. Researchers should empirically determine the suitability of the RPA2 rpa2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RPA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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